Trefoil factors in inflammatory bowel disease

Luise Aamann, Else Marie Vestergaard, Henning Grønbæk

Abstract

Inflammatory bowel disease (IBD), which comprises ulcerative colitis and Crohn's disease, is characterized by inflammation of the gastrointestinal tract. The trefoil factors 1, 2, and 3 (TFF1-3) are a family of peptides that play important roles in the protection and repair of epithelial surfaces, including the gastrointestinal tract. TFFs may be involved in IBD pathogenesis and are a potential treatment option. In the present review, we describe the TFF family and their potential role in IBD by summarizing the current knowledge of their expression, possible function and pharmacological role in IBD.

OriginalsprogEngelsk
TidsskriftWorld Journal of Gastroenterology
Vol/bind20
Udgave nummer12
Sider (fra-til)3223-30
Antal sider8
ISSN1007-9327
DOI
StatusUdgivet - 28 mar. 2014

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