Treatment with antidepressants and lithium is associated with increased risk of treatment with antiparkinson drugs: a pharmacoepidemiological study

M Brandt-Christensen; K Kvist; F M Nilsson; P K Andersen; L V Kessing

doi:10.1136/jnnp.2005.083345

Treatment with antidepressants and lithium is associated with increased risk of treatment with antiparkinson drugs: a pharmacoepidemiological study

M Brandt-Christensen, K Kvist, F M Nilsson, P K Andersen, L V Kessing

23 Citationer (Scopus)

Abstract

OBJECTIVE: To estimate the risk for persons treated with antidepressants or lithium of subsequent treatment with antiparkinson drugs (APD).

METHODS: The Danish national prescription database supplied data on all persons who received antidepressants, lithium, or antidiabetics (first control group). A second control group was included comprising persons from the general population. Outcome was purchase of APD and the study period was 1995 to 1999.

RESULTS: In total, 1 293 789 persons were included. The rate ratio of treatment with APD after treatment with antidepressants was 2.27 (95% CI 2.14 to 2.42) for men and 1.50 (95% CI 1.43 to 1.58) for women. Figures for lithium were almost identical.

CONCLUSION: Persons treated with antidepressants or lithium are at increased risk of subsequently treatment with APD, showing an association between anxiety/affective disorder and Parkinson's disease.

Originalsprog	Engelsk
Tidsskrift	Journal of neurology, neurosurgery, and psychiatry
Vol/bind	77
Udgave nummer	6
Sider (fra-til)	781-3
Antal sider	3
ISSN	0022-3050
DOI	https://doi.org/10.1136/jnnp.2005.083345
Status	Udgivet - jun. 2006

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10.1136/jnnp.2005.083345

Citationsformater

Treatment with antidepressants and lithium is associated with increased risk of treatment with antiparkinson drugs: a pharmacoepidemiological study. / Brandt-Christensen, M; Kvist, K ; Nilsson, F M et al.
I: Journal of neurology, neurosurgery, and psychiatry, Bind 77, Nr. 6, 06.2006, s. 781-3.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "Treatment with antidepressants and lithium is associated with increased risk of treatment with antiparkinson drugs: a pharmacoepidemiological study",

abstract = "OBJECTIVE: To estimate the risk for persons treated with antidepressants or lithium of subsequent treatment with antiparkinson drugs (APD).METHODS: The Danish national prescription database supplied data on all persons who received antidepressants, lithium, or antidiabetics (first control group). A second control group was included comprising persons from the general population. Outcome was purchase of APD and the study period was 1995 to 1999.RESULTS: In total, 1 293 789 persons were included. The rate ratio of treatment with APD after treatment with antidepressants was 2.27 (95% CI 2.14 to 2.42) for men and 1.50 (95% CI 1.43 to 1.58) for women. Figures for lithium were almost identical.CONCLUSION: Persons treated with antidepressants or lithium are at increased risk of subsequently treatment with APD, showing an association between anxiety/affective disorder and Parkinson's disease.",

keywords = "Antidepressive Agents, Antimanic Agents, Antiparkinson Agents, Anxiety Disorders, Case-Control Studies, Denmark, Drug Prescriptions, Epidemiologic Studies, Female, Humans, Lithium Carbonate, Male, Mood Disorders, Parkinson Disease, Pharmacoepidemiology, Risk Factors, Journal Article",

author = "M Brandt-Christensen and K Kvist and Nilsson, {F M} and Andersen, {P K} and Kessing, {L V}",

year = "2006",

month = jun,

doi = "10.1136/jnnp.2005.083345",

language = "English",

volume = "77",

pages = "781--3",

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TY - JOUR

T1 - Treatment with antidepressants and lithium is associated with increased risk of treatment with antiparkinson drugs

T2 - a pharmacoepidemiological study

AU - Brandt-Christensen, M

AU - Kvist, K

AU - Nilsson, F M

AU - Andersen, P K

AU - Kessing, L V

PY - 2006/6

Y1 - 2006/6

N2 - OBJECTIVE: To estimate the risk for persons treated with antidepressants or lithium of subsequent treatment with antiparkinson drugs (APD).METHODS: The Danish national prescription database supplied data on all persons who received antidepressants, lithium, or antidiabetics (first control group). A second control group was included comprising persons from the general population. Outcome was purchase of APD and the study period was 1995 to 1999.RESULTS: In total, 1 293 789 persons were included. The rate ratio of treatment with APD after treatment with antidepressants was 2.27 (95% CI 2.14 to 2.42) for men and 1.50 (95% CI 1.43 to 1.58) for women. Figures for lithium were almost identical.CONCLUSION: Persons treated with antidepressants or lithium are at increased risk of subsequently treatment with APD, showing an association between anxiety/affective disorder and Parkinson's disease.

AB - OBJECTIVE: To estimate the risk for persons treated with antidepressants or lithium of subsequent treatment with antiparkinson drugs (APD).METHODS: The Danish national prescription database supplied data on all persons who received antidepressants, lithium, or antidiabetics (first control group). A second control group was included comprising persons from the general population. Outcome was purchase of APD and the study period was 1995 to 1999.RESULTS: In total, 1 293 789 persons were included. The rate ratio of treatment with APD after treatment with antidepressants was 2.27 (95% CI 2.14 to 2.42) for men and 1.50 (95% CI 1.43 to 1.58) for women. Figures for lithium were almost identical.CONCLUSION: Persons treated with antidepressants or lithium are at increased risk of subsequently treatment with APD, showing an association between anxiety/affective disorder and Parkinson's disease.

KW - Antidepressive Agents

KW - Antimanic Agents

KW - Antiparkinson Agents

KW - Anxiety Disorders

KW - Case-Control Studies

KW - Denmark

KW - Drug Prescriptions

KW - Epidemiologic Studies

KW - Female

KW - Humans

KW - Lithium Carbonate

KW - Male

KW - Mood Disorders

KW - Parkinson Disease

KW - Pharmacoepidemiology

KW - Risk Factors

KW - Journal Article

U2 - 10.1136/jnnp.2005.083345

DO - 10.1136/jnnp.2005.083345

M3 - Journal article

C2 - 16705201

SN - 0022-3050

VL - 77

SP - 781

EP - 783

JO - Journal of neurology, neurosurgery, and psychiatry

JF - Journal of neurology, neurosurgery, and psychiatry

IS - 6

ER -

Treatment with antidepressants and lithium is associated with increased risk of treatment with antiparkinson drugs: a pharmacoepidemiological study

Abstract

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