Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort

Z Vegh; J Burisch; N Pedersen; I Kaimakliotis; D Duricova; M Bortlik; Kristoffer Kofod Vinding; Søren Avnstrøm; J Olsen; K R Nielsen; K H Katsanos; E V Tsianos; L Lakatos; D Schwartz; S Odes; R D'Incà; M Beltrami; G Kiudelis; L Kupcinskas; A Jucov; S Turcan; L F Barros; F Magro; D Lazar; A Goldis; L de Castro; V Hernandez; O Niewiadomski; S Bell; Ebbe Langholz; P Munkholm; P L Lakatos

doi:10.1093/ecco-jcc/jjv099

Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort

Z Vegh, J Burisch, N Pedersen, I Kaimakliotis, D Duricova, M Bortlik, Kristoffer Kofod Vinding, Søren Avnstrøm, J Olsen, K R Nielsen, K H Katsanos, E V Tsianos, L Lakatos, D Schwartz, S Odes, R D'Incà, M Beltrami, G Kiudelis, L Kupcinskas, A JucovS Turcan, L F Barros, F Magro, D Lazar, A Goldis, L de Castro, V Hernandez, O Niewiadomski, S Bell, Ebbe Langholz, P Munkholm, P L Lakatos

35 Citationer (Scopus)

Abstract

BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases (IBD) between Eastern and Western Europe. The aim of this study was to analyze the differences in the disease phenotype, medical therapy, surgery and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.

METHODS: Nine Western, five Eastern European centers and one Australian center with 258 Crohn's disease (CD), 380 ulcerative colitis (UC) and 71 IBD unclassified (IBDU) patients (female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years) participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database (www.epicom-ecco.eu).

RESULTS: In CD, 36 (19%) Western Europe/Australian and 6 (9%) Eastern European patients received biological therapy (p=0.04), but the immunosuppressive (IS) use was equal and high in these regions (Eastern Europe vs. Western Europe/Australia: 53% vs. 45%; p=0.27). Surgery was performed in 17 (24%) CD patients in Eastern Europe and 13 (7%) in Western Europe/Australia (p<0.001, pLogRank=0.001). Twenty-four (34%) CD patients from Eastern Europe and 39 (21%) from Western Europe/Australia were hospitalized (p=0.02, pLogRank=0.01). In UC, exposure to biologics and colectomy rates were low and hospitalization rates did not differ between these regions during the one-year follow-up period (16% vs. 16%; p=0.93).

CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared to Western Europe/Australia, while significantly more CD patients were treated with biologicals in the Western Europe/Australian centers.

Originalsprog	Engelsk
Tidsskrift	Journal of Crohn's & colitis
Vol/bind	9
Udgave nummer	9
Sider (fra-til)	747-753
ISSN	1873-9946
DOI	https://doi.org/10.1093/ecco-jcc/jjv099
Status	Udgivet - 7 jun. 2015

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10.1093/ecco-jcc/jjv099

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Vegh, Z., Burisch, J., Pedersen, N., Kaimakliotis, I., Duricova, D., Bortlik, M., Vinding, K. K., Avnstrøm, S., Olsen, J., Nielsen, K. R., Katsanos, K. H., Tsianos, E. V., Lakatos, L., Schwartz, D., Odes, S., D'Incà, R., Beltrami, M., Kiudelis, G., Kupcinskas, L., ... Lakatos, P. L. (2015). Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort. Journal of Crohn's & colitis, 9(9), 747-753. https://doi.org/10.1093/ecco-jcc/jjv099

Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort. / Vegh, Z; Burisch, J; Pedersen, N et al.
I: Journal of Crohn's & colitis, Bind 9, Nr. 9, 07.06.2015, s. 747-753.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Vegh, Z, Burisch, J, Pedersen, N, Kaimakliotis, I, Duricova, D, Bortlik, M, Vinding, KK, Avnstrøm, S, Olsen, J, Nielsen, KR, Katsanos, KH, Tsianos, EV, Lakatos, L, Schwartz, D, Odes, S, D'Incà, R, Beltrami, M, Kiudelis, G, Kupcinskas, L, Jucov, A, Turcan, S, Barros, LF, Magro, F, Lazar, D, Goldis, A, de Castro, L, Hernandez, V, Niewiadomski, O, Bell, S, Langholz, E , Munkholm, P & Lakatos, PL 2015, 'Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort', Journal of Crohn's & colitis, bind 9, nr. 9, s. 747-753. https://doi.org/10.1093/ecco-jcc/jjv099

@article{2f1b26ab23cc43af89b756efe127765c,

title = "Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort",

abstract = "BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases (IBD) between Eastern and Western Europe. The aim of this study was to analyze the differences in the disease phenotype, medical therapy, surgery and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.METHODS: Nine Western, five Eastern European centers and one Australian center with 258 Crohn's disease (CD), 380 ulcerative colitis (UC) and 71 IBD unclassified (IBDU) patients (female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years) participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database (www.epicom-ecco.eu).RESULTS: In CD, 36 (19%) Western Europe/Australian and 6 (9%) Eastern European patients received biological therapy (p=0.04), but the immunosuppressive (IS) use was equal and high in these regions (Eastern Europe vs. Western Europe/Australia: 53% vs. 45%; p=0.27). Surgery was performed in 17 (24%) CD patients in Eastern Europe and 13 (7%) in Western Europe/Australia (p<0.001, pLogRank=0.001). Twenty-four (34%) CD patients from Eastern Europe and 39 (21%) from Western Europe/Australia were hospitalized (p=0.02, pLogRank=0.01). In UC, exposure to biologics and colectomy rates were low and hospitalization rates did not differ between these regions during the one-year follow-up period (16% vs. 16%; p=0.93).CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared to Western Europe/Australia, while significantly more CD patients were treated with biologicals in the Western Europe/Australian centers.",

author = "Z Vegh and J Burisch and N Pedersen and I Kaimakliotis and D Duricova and M Bortlik and Vinding, {Kristoffer Kofod} and S{\o}ren Avnstr{\o}m and J Olsen and Nielsen, {K R} and Katsanos, {K H} and Tsianos, {E V} and L Lakatos and D Schwartz and S Odes and R D'Inc{\`a} and M Beltrami and G Kiudelis and L Kupcinskas and A Jucov and S Turcan and Barros, {L F} and F Magro and D Lazar and A Goldis and {de Castro}, L and V Hernandez and O Niewiadomski and S Bell and Ebbe Langholz and P Munkholm and Lakatos, {P L}",

note = "Copyright {\textcopyright} 2015 European Crohn{\textquoteright}s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected].",

year = "2015",

month = jun,

day = "7",

doi = "10.1093/ecco-jcc/jjv099",

language = "English",

volume = "9",

pages = "747--753",

journal = "Journal of Crohn's & colitis",

issn = "1873-9946",

publisher = "Oxford University Press",

number = "9",

}

TY - JOUR

T1 - Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort

AU - Vegh, Z

AU - Burisch, J

AU - Pedersen, N

AU - Kaimakliotis, I

AU - Duricova, D

AU - Bortlik, M

AU - Vinding, Kristoffer Kofod

AU - Avnstrøm, Søren

AU - Olsen, J

AU - Nielsen, K R

AU - Katsanos, K H

AU - Tsianos, E V

AU - Lakatos, L

AU - Schwartz, D

AU - Odes, S

AU - D'Incà, R

AU - Beltrami, M

AU - Kiudelis, G

AU - Kupcinskas, L

AU - Jucov, A

AU - Turcan, S

AU - Barros, L F

AU - Magro, F

AU - Lazar, D

AU - Goldis, A

AU - de Castro, L

AU - Hernandez, V

AU - Niewiadomski, O

AU - Bell, S

AU - Langholz, Ebbe

AU - Munkholm, P

AU - Lakatos, P L

PY - 2015/6/7

Y1 - 2015/6/7

N2 - BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases (IBD) between Eastern and Western Europe. The aim of this study was to analyze the differences in the disease phenotype, medical therapy, surgery and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.METHODS: Nine Western, five Eastern European centers and one Australian center with 258 Crohn's disease (CD), 380 ulcerative colitis (UC) and 71 IBD unclassified (IBDU) patients (female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years) participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database (www.epicom-ecco.eu).RESULTS: In CD, 36 (19%) Western Europe/Australian and 6 (9%) Eastern European patients received biological therapy (p=0.04), but the immunosuppressive (IS) use was equal and high in these regions (Eastern Europe vs. Western Europe/Australia: 53% vs. 45%; p=0.27). Surgery was performed in 17 (24%) CD patients in Eastern Europe and 13 (7%) in Western Europe/Australia (p<0.001, pLogRank=0.001). Twenty-four (34%) CD patients from Eastern Europe and 39 (21%) from Western Europe/Australia were hospitalized (p=0.02, pLogRank=0.01). In UC, exposure to biologics and colectomy rates were low and hospitalization rates did not differ between these regions during the one-year follow-up period (16% vs. 16%; p=0.93).CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared to Western Europe/Australia, while significantly more CD patients were treated with biologicals in the Western Europe/Australian centers.

AB - BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases (IBD) between Eastern and Western Europe. The aim of this study was to analyze the differences in the disease phenotype, medical therapy, surgery and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.METHODS: Nine Western, five Eastern European centers and one Australian center with 258 Crohn's disease (CD), 380 ulcerative colitis (UC) and 71 IBD unclassified (IBDU) patients (female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years) participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database (www.epicom-ecco.eu).RESULTS: In CD, 36 (19%) Western Europe/Australian and 6 (9%) Eastern European patients received biological therapy (p=0.04), but the immunosuppressive (IS) use was equal and high in these regions (Eastern Europe vs. Western Europe/Australia: 53% vs. 45%; p=0.27). Surgery was performed in 17 (24%) CD patients in Eastern Europe and 13 (7%) in Western Europe/Australia (p<0.001, pLogRank=0.001). Twenty-four (34%) CD patients from Eastern Europe and 39 (21%) from Western Europe/Australia were hospitalized (p=0.02, pLogRank=0.01). In UC, exposure to biologics and colectomy rates were low and hospitalization rates did not differ between these regions during the one-year follow-up period (16% vs. 16%; p=0.93).CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared to Western Europe/Australia, while significantly more CD patients were treated with biologicals in the Western Europe/Australian centers.

U2 - 10.1093/ecco-jcc/jjv099

DO - 10.1093/ecco-jcc/jjv099

M3 - Journal article

C2 - 26055976

SN - 1873-9946

VL - 9

SP - 747

EP - 753

JO - Journal of Crohn's & colitis

JF - Journal of Crohn's & colitis

IS - 9

ER -

Treatment steps, surgery and hospitalization rates during the first year of follow-up in patients with inflammatory bowel diseases from the 2011 ECCO-EpiCom inception cohort

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