Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors-A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS)

Line Kenborg; Peter H Asdahl; Smita Bhatia; Jane Christensen; Thorgerdur Gudmundsdottir; Lars Hjorth; Rebecca Howell; Anja Krøyer; Morten Jørgensen; Michael R T Laursen; Yasmin Lassen-Ramshad; Sofie de Fine Licht; Thomas Tjørnelund Nielsen; Catherine Rechnitzer; Susan A Smith; Thomas Wiebe; Henrik Hasle; Anna S Holmqvist; ALiCCS study group

doi:10.1002/pbc.31805

Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors-A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS)

Line Kenborg, Peter H Asdahl, Smita Bhatia, Jane Christensen, Thorgerdur Gudmundsdottir, Lars Hjorth, Rebecca Howell, Anja Krøyer, Morten Jørgensen, Michael R T Laursen, Yasmin Lassen-Ramshad, Sofie de Fine Licht, Thomas Tjørnelund Nielsen, Catherine Rechnitzer, Susan A Smith, Thomas Wiebe, Henrik Hasle, Anna S Holmqvist^*, ALiCCS study group

^*Corresponding author af dette arbejde

Abstract

The aim was to identify treatment-related risk factors for diabetes in 5-year survivors of childhood cancer (CCS). This case-cohort study within Adult Life after Childhood Cancer in Scandinavia (ALiCCS) included 140 CCS with diabetes and a subcohort of 390 randomly selected CCS. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated to assess the association between treatment exposures and diabetes. Radiotherapy was the most important risk factor, with increased IRR after total body irradiation (TBI) (9.8, 95% CI = 2.9-33.7), abdominal radiation (4.8, 95% CI = 2.2-10.4), and cranial radiation (4.3, 95% CI = 2.1-8.8). Continued follow-up with regard to diabetes is indicated after TBI, abdominal radiation, and cranial radiation in CCS.

Originalsprog	Engelsk
Artikelnummer	e31805
Tidsskrift	Pediatric Blood & Cancer
Vol/bind	72
Udgave nummer	8
ISSN	1545-5009
DOI	https://doi.org/10.1002/pbc.31805
Status	Udgivet - aug. 2025

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10.1002/pbc.31805Licens: CC BY-NC-ND

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Kenborg, L., Asdahl, P. H., Bhatia, S., Christensen, J., Gudmundsdottir, T., Hjorth, L., Howell, R., Krøyer, A., Jørgensen, M., Laursen, M. R. T., Lassen-Ramshad, Y., de Fine Licht, S., Nielsen, T. T., Rechnitzer, C., Smith, S. A., Wiebe, T., Hasle, H., Holmqvist, A. S., & ALiCCS study group (2025). Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors-A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS). Pediatric Blood & Cancer, 72(8), Artikel e31805. https://doi.org/10.1002/pbc.31805

Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors-A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS). / Kenborg, Line; Asdahl, Peter H; Bhatia, Smita et al.
I: Pediatric Blood & Cancer, Bind 72, Nr. 8, e31805, 08.2025.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Kenborg, L, Asdahl, PH, Bhatia, S, Christensen, J, Gudmundsdottir, T, Hjorth, L, Howell, R, Krøyer, A, Jørgensen, M , Laursen, MRT, Lassen-Ramshad, Y, de Fine Licht, S, Nielsen, TT, Rechnitzer, C, Smith, SA, Wiebe, T, Hasle, H, Holmqvist, AS & ALiCCS study group 2025, 'Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors-A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS)', Pediatric Blood & Cancer, bind 72, nr. 8, e31805. https://doi.org/10.1002/pbc.31805

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title = "Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors-A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS)",

abstract = "The aim was to identify treatment-related risk factors for diabetes in 5-year survivors of childhood cancer (CCS). This case-cohort study within Adult Life after Childhood Cancer in Scandinavia (ALiCCS) included 140 CCS with diabetes and a subcohort of 390 randomly selected CCS. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated to assess the association between treatment exposures and diabetes. Radiotherapy was the most important risk factor, with increased IRR after total body irradiation (TBI) (9.8, 95% CI = 2.9-33.7), abdominal radiation (4.8, 95% CI = 2.2-10.4), and cranial radiation (4.3, 95% CI = 2.1-8.8). Continued follow-up with regard to diabetes is indicated after TBI, abdominal radiation, and cranial radiation in CCS.",

keywords = "Adolescent, Adult, Cancer Survivors/statistics & numerical data, Case-Control Studies, Child, Child, Preschool, Cohort Studies, Diabetes Mellitus/etiology, Female, Follow-Up Studies, Humans, Incidence, Infant, Male, Neoplasms/therapy, Prognosis, Risk Factors, Scandinavian and Nordic Countries/epidemiology, Whole-Body Irradiation/adverse effects, Young Adult, risk factors, childhood cancer survivors, diabetes, late effects",

author = "Line Kenborg and Asdahl, {Peter H} and Smita Bhatia and Jane Christensen and Thorgerdur Gudmundsdottir and Lars Hjorth and Rebecca Howell and Anja Kr{\o}yer and Morten J{\o}rgensen and Laursen, {Michael R T} and Yasmin Lassen-Ramshad and {de Fine Licht}, Sofie and Nielsen, {Thomas Tj{\o}rnelund} and Catherine Rechnitzer and Smith, {Susan A} and Thomas Wiebe and Henrik Hasle and Holmqvist, {Anna S} and {ALiCCS study group}",

note = "{\textcopyright} 2025 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC.",

year = "2025",

month = aug,

doi = "10.1002/pbc.31805",

language = "English",

volume = "72",

journal = "Pediatric Blood & Cancer",

issn = "1545-5009",

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T1 - Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors-A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS)

AU - Kenborg, Line

AU - Asdahl, Peter H

AU - Bhatia, Smita

AU - Christensen, Jane

AU - Gudmundsdottir, Thorgerdur

AU - Hjorth, Lars

AU - Howell, Rebecca

AU - Krøyer, Anja

AU - Jørgensen, Morten

AU - Laursen, Michael R T

AU - Lassen-Ramshad, Yasmin

AU - de Fine Licht, Sofie

AU - Nielsen, Thomas Tjørnelund

AU - Rechnitzer, Catherine

AU - Smith, Susan A

AU - Wiebe, Thomas

AU - Hasle, Henrik

AU - Holmqvist, Anna S

AU - ALiCCS study group

PY - 2025/8

Y1 - 2025/8

N2 - The aim was to identify treatment-related risk factors for diabetes in 5-year survivors of childhood cancer (CCS). This case-cohort study within Adult Life after Childhood Cancer in Scandinavia (ALiCCS) included 140 CCS with diabetes and a subcohort of 390 randomly selected CCS. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated to assess the association between treatment exposures and diabetes. Radiotherapy was the most important risk factor, with increased IRR after total body irradiation (TBI) (9.8, 95% CI = 2.9-33.7), abdominal radiation (4.8, 95% CI = 2.2-10.4), and cranial radiation (4.3, 95% CI = 2.1-8.8). Continued follow-up with regard to diabetes is indicated after TBI, abdominal radiation, and cranial radiation in CCS.

AB - The aim was to identify treatment-related risk factors for diabetes in 5-year survivors of childhood cancer (CCS). This case-cohort study within Adult Life after Childhood Cancer in Scandinavia (ALiCCS) included 140 CCS with diabetes and a subcohort of 390 randomly selected CCS. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated to assess the association between treatment exposures and diabetes. Radiotherapy was the most important risk factor, with increased IRR after total body irradiation (TBI) (9.8, 95% CI = 2.9-33.7), abdominal radiation (4.8, 95% CI = 2.2-10.4), and cranial radiation (4.3, 95% CI = 2.1-8.8). Continued follow-up with regard to diabetes is indicated after TBI, abdominal radiation, and cranial radiation in CCS.

KW - Adolescent

KW - Adult

KW - Cancer Survivors/statistics & numerical data

KW - Case-Control Studies

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Diabetes Mellitus/etiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Infant

KW - Male

KW - Neoplasms/therapy

KW - Prognosis

KW - Risk Factors

KW - Scandinavian and Nordic Countries/epidemiology

KW - Whole-Body Irradiation/adverse effects

KW - Young Adult

KW - risk factors

KW - childhood cancer survivors

KW - diabetes

KW - late effects

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U2 - 10.1002/pbc.31805

DO - 10.1002/pbc.31805

M3 - Journal article

C2 - 40399750

SN - 1545-5009

VL - 72

JO - Pediatric Blood & Cancer

JF - Pediatric Blood & Cancer

IS - 8

M1 - e31805

ER -

Treatment-Related Risk Factors for Diabetes Mellitus in Childhood Cancer Survivors-A Case-Cohort Study Within Adult Life After Childhood Cancer in Scandinavia (ALiCCS)

Abstract

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