Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Treatment outcome in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study (ESOS)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Ariane L Herrick
  • Xiaoyan Pan
  • Sébastien Peytrignet
  • Mark Lunt
  • Roger Hesselstrand
  • Luc Mouthon
  • Alan Silman
  • Edith Brown
  • László Czirják
  • Jörg H W Distler
  • Oliver Distler
  • Kim Fligelstone
  • William J Gregory
  • Rachel Ochiel
  • Madelon Vonk
  • Codrina Ancuţa
  • Voon H Ong
  • Dominique Farge
  • Marie Hudson
  • Marco Matucci-Cerinic
  • Alexandra Balbir-Gurman
  • Øyvind Midtvedt
  • Alison C Jordan
  • Paresh Jobanputra
  • Wendy Stevens
  • Pia Moinzadeh
  • Frances C Hall
  • Christian Agard
  • Marina E Anderson
  • Elisabeth Diot
  • Rajan Madhok
  • Mohammed Akil
  • Maya H Buch
  • Lorinda Chung
  • Nemanja Damjanov
  • Harsha Gunawardena
  • Peter Lanyon
  • Yasmeen Ahmad
  • Kuntal Chakravarty
  • Søren Jacobsen
  • Alexander J MacGregor
  • Neil McHugh
  • Ulf Müller-Ladner
  • Gabriela Riemekasten
  • Michael Becker
  • Janet Roddy
  • Patricia E Carreira
  • Anne Laure Fauchais
  • Eric Hachulla
  • Jennifer Hamilton
  • Murat İnanç
  • John S McLaren
  • Jacob M van Laar
  • Sanjay Pathare
  • Susannah Proudman
  • Anna Rudin
  • Joanne Sahhar
  • Brigitte Coppere
  • Christine Serratrice
  • Tom Sheeran
  • Douglas J Veale
  • Claire Grange
  • Georges-Selim Trad
  • Christopher P Denton
Vis graf over relationer

OBJECTIVES: The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment approaches.

METHODS: This was a prospective, observational cohort study of early dcSSc (within three years of onset of skin thickening). Clinicians selected one of four protocols for each patient: methotrexate, mycophenolate mofetil (MMF), cyclophosphamide or 'no immunosuppressant'. Patients were assessed three-monthly for up to 24 months. The primary outcome was the change in modified Rodnan skin score (mRSS). Confounding by indication at baseline was accounted for using inverse probability of treatment (IPT) weights. As a secondary outcome, an IPT-weighted Cox model was used to test for differences in survival.

RESULTS: Of 326 patients recruited from 50 centres, 65 were prescribed methotrexate, 118 MMF, 87 cyclophosphamide and 56 no immunosuppressant. 276 (84.7%) patients completed 12 and 234 (71.7%) 24 months follow-up (or reached last visit date). There were statistically significant reductions in mRSS at 12 months in all groups: -4.0 (-5.2 to -2.7) units for methotrexate, -4.1 (-5.3 to -2.9) for MMF, -3.3 (-4.9 to -1.7) for cyclophosphamide and -2.2 (-4.0 to -0.3) for no immunosuppressant (p value for between-group differences=0.346). There were no statistically significant differences in survival between protocols before (p=0.389) or after weighting (p=0.440), but survival was poorest in the no immunosuppressant group (84.0%) at 24 months.

CONCLUSIONS: These findings may support using immunosuppressants for early dcSSc but suggest that overall benefit is modest over 12 months and that better treatments are needed.


TidsskriftAnnals of the Rheumatic Diseases
Udgave nummer7
Sider (fra-til)1207-1218
Antal sider12
StatusUdgivet - jul. 2017

ID: 52379954