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Treatment of older patients with mantle-cell lymphoma

  • H C Kluin-Nelemans
  • , E Hoster
  • , O Hermine
  • , J Walewski
  • , M Trneny
  • , C H Geisler
  • , S Stilgenbauer
  • , C Thieblemont
  • , U Vehling-Kaiser
  • , J K Doorduijn
  • , B Coiffier
  • , R Forstpointner
  • , H Tilly
  • , L Kanz
  • , P Feugier
  • , M Szymczyk
  • , M Hallek
  • , S Kremers
  • , G Lepeu
  • , L Sanhes
  • J M Zijlstra, R Bouabdallah, P J Lugtenburg, M Macro, M Pfreundschuh, V Procházka, F Di Raimondo, V Ribrag, M Uppenkamp, M André, W Klapper, W Hiddemann, M Unterhalt, M H Dreyling
    480 Citationer (Scopus)

    Abstract

    The long-term prognosis for older patients with mantle-cell lymphoma is poor. Chemoimmunotherapy results in low rates of complete remission, and most patients have a relapse. We investigated whether a fludarabine-containing induction regimen improved the complete-remission rate and whether maintenance therapy with rituximab prolonged remission.
    OriginalsprogEngelsk
    TidsskriftNew England Journal of Medicine
    Vol/bind367
    Udgave nummer6
    Sider (fra-til)520-31
    Antal sider12
    ISSN0028-4793
    DOI
    StatusUdgivet - 2012

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