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Region Hovedstaden - en del af Københavns Universitetshospital
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Treatment history and outcome of 24 deliveries worldwide after autotransplantation of cryopreserved ovarian tissue, including two new Danish deliveries years after autotransplantation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Improving the maturation rate of human oocytes collected ex vivo during the cryopreservation of ovarian tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Ovarian cortical follicle density in infertile women with low anti-Müllerian hormone

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Transcription profile of the insulin-like growth factor signaling pathway during human ovarian follicular development

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Expression of the Insulin-like Growth Factor System in First- and Second-Trimester Human Embryonic and Fetal Gonads

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Futures and fears in the freezer: Danish women's experiences with ovarian tissue cryopreservation and transplantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Shortcomings of an unphysiological triggering of oocyte maturation using human chorionic gonadotropin

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Surrogate testes: Allogeneic spermatogonial stem cell transplantation within an encapsulation device may restore male fertility

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Effect of sphingosine-1-phosphate on activation of dormant follicles in murine and human ovarian tissue

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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PURPOSE: To report another two successful pregnancies and deliveries resulting from autotransplanted cryopreserved ovarian tissue several years after the autotransplantation procedure took place. Further, to review the literature on the treatment history, number of live births and their outcome so far reported worldwide.

METHODS: Two women underwent fertility preservation with cryopreservation of their ovarian tissue prior to a potentially sterilizing treatment with bone marrow transplantation. One woman suffered from paroxystic nocturnal hemoglobinuria and one woman from relapse of Hodgkin's lymphoma. Both suffered from premature ovarian insufficiency after treatment. Because of a pregnancy wish they later had pieces of thawed cortical tissue transplanted to the remaining ovary and the anterior abdominal wall. PubMed was searched for reports of deliveries resulting from cryopreserved ovarian tissue in peer-reviewed papers.

RESULTS: Five years after the autotransplantation the first patient became spontaneously pregnant and delivered a healthy baby boy at term. The second patient became pregnant after undergoing one cycle of in vitro fertilisation five years after the autotransplantation. She delivered a healthy baby boy at gestational week 36. Twenty healthy singletons and two sets of twins have been born according to peer-reviewed publications.

CONCLUSION: Contrary to most of the published deliveries our latest two cases occurred several years after the autotransplantation procedure took place. This proves that ovarian grafts are capable of functioning for several years after the autotransplantation has occurred. Today, a total of 26 healthy children have been born as a result of cryopreservation of ovarian tissue.

OriginalsprogEngelsk
TidsskriftJournal of Assisted Reproduction and Genetics
Vol/bind31
Udgave nummer11
Sider (fra-til)1557-64
Antal sider8
ISSN1058-0468
DOI
StatusUdgivet - nov. 2014

ID: 44889102