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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Traumatic brain injury and risk of dementia at different levels of cognitive ability and education

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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BACKGROUND AND PURPOSE: The effect of cognitive resources on the risk of dementia following traumatic brain injury (TBI) has been scarcely investigated. The aim of this study was to examine the influence of cognitive ability and education in young adulthood on the association between TBI and dementia in men.

METHOD: A cohort of 658,447 Danish men, born 1939-1959, who had been cognitively assessed at conscription were followed in the Danish National Patient Registry and the National Prescription Registry from 1977 through 2016 for incident TBI and dementia. The association between TBI and dementia was analysed using Cox proportional regression.

RESULTS: During follow-up, 29,781(4.5%) men experienced TBI and 10 971(1.7%) developed dementia. TBI was associated with higher risk of subsequent dementia after adjustment for cognitive ability, education and psychiatric comorbidity. The risk estimate was higher for early-onset dementia (hazard ratio (HR)=5.49 (4.97-6.06)) than for dementia diagnosed after age 60 years (HR= 2.85 (2.63-3.10). The association was slightly stronger in men with the highest cognitive scores or education than among those at lower levels CONCLUSION: Young adult cognitive ability did not explain a relatively strong association between TBI and dementia, and we found no evidence that cognitive ability or education were protective.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Neurology
ISSN1351-5101
DOI
StatusE-pub ahead of print - 30 sep. 2019

Bibliografisk note

© 2019 EAN.

ID: 58075094