Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Transversus abdominis plane block after laparoscopic colonic resection in cancer patients: A randomised clinical trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Ten years of the Helsinki Declaration on patient safety in anaesthesiology: An expert opinion on peri-operative safety aspects

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Noninvasive respiratory support in the hypoxaemic peri-operative/periprocedural patient: A joint ESA/ESICM guideline

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Reply to: will one hour less make any difference?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Functional recovery after knee arthroplasty with regional analgesia

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  5. Air embolism during venous sheath replacement

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. APACHE II score validation in emergency abdominal surgery. A post hoc analysis of the InCare trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Closure of the fascial defect during laparoscopic umbilical hernia repair: a randomized clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Incidence of Inguinal Hernia after Radical Prostatectomy: A Systematic Review and Meta-Analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: A key point in pathways for optimal rehabilitation and enhanced recovery is an effective postoperative multimodal pain treatment regimen.

OBJECTIVE: To investigate the analgesic effects of transversus abdominis plane (TAP) block in conjunction with paracetamol and ibuprofen in patients undergoing laparoscopic colonic resection.

DESIGN: Randomised placebo-controlled double-blind study.

SETTING: Herlev University Hospital, Copenhagen, Denmark, from March 2010 to February 2013.

PATIENTS: Eighty adult patients scheduled for elective laparoscopic colectomy.

INTERVENTIONS: Bilateral TAP block with 20 ml of either ropivacaine or isotonic saline.

MAIN OUTCOME MEASURES: Visual analogue scale (VAS) pain scores (0 to 100 mm) while coughing at 6 h after surgery (primary outcome). Secondary outcomes were area under the curve pain scores (2 to 24 h) at rest and while coughing, 24-h morphine consumption and incidence of nausea and vomiting.

RESULTS: VAS pain scores at 6 h while coughing was not different between groups (median, interquartile range), TAP, 27 (11 to 45) mm vs. placebo, 33 (20 to 49) mm (P = 0.20). Total 24-h morphine consumption was reduced in the TAP block group vs. placebo group, 30 (15 to 41) mg vs. 43 (30 to 67) mg, respectively (P = 0.008). This difference was most pronounced in the first postoperative hours. The remaining outcomes did not differ between groups.

CONCLUSION: TAP block used in combination with paracetamol and ibuprofen did not reduce pain after laparoscopic colonic surgery. However, we found a 30% reduction in opioid use, most marked in the early postoperative period.

TRIAL REGISTRATION: www.clinicaltrials.gov (NCT01418144).

OriginalsprogEngelsk
TidsskriftEuropean Journal of Anaesthesiology
Vol/bind33
Udgave nummer10
Sider (fra-til)725-30
Antal sider6
ISSN0265-0215
DOI
StatusUdgivet - okt. 2016

ID: 49288929