Transfer of maternal IgE can be a common cause of increased IgE levels in cord blood

Klaus Bønnelykke, Christian Bressen Pipper, Hans Bisgaard

44 Citationer (Scopus)

Abstract

IgE in cord blood is thought to be a product of the fetus. A high level of total IgE is therefore used as a measure of atopic propensity in the newborn. We recently found strong evidence that allergen-specific IgE in cord blood was the result of transfer of maternal IgE to fetal blood or cord blood (maternofetal transfer) rather than fetal production. This also suggests that total IgE in cord blood might primarily be a maternal product.
OriginalsprogEngelsk
TidsskriftThe Journal of allergy and clinical immunology
Vol/bind126
Udgave nummer3
Sider (fra-til)657-63
Antal sider7
DOI
StatusUdgivet - 1 sep. 2010

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