Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Transdiagnostic group CBT vs. standard group CBT for depression, social anxiety disorder and agoraphobia/panic disorder: Study protocol for a pragmatic, multicenter non-inferiority randomized controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Psychiatric comorbidity in individuals with bullous pemphigoid and all bullous disorders in the Danish national registers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Case report: cognitive performance in an extreme case of anorexia nervosa with a body mass index of 7.7

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The impact of parental psychopathology and sociodemographic factors in selective mutism - a nationwide population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Variability between psychiatrists on domains of the mental status examination

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. E-Library of Authentic Patient Videos Improves Medical Students' Mental Status Examination

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Arguments for a Phenomenologically Informed Clinical Approach to Autism Spectrum Disorder

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Transdiagnostic group CBT for anxiety disorders: the unified protocol in mental health services

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Cognitive behavioural therapy for ADHD in adults: systematic review and meta-analyses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Transdiagnostic Cognitive Behavior Therapy (TCBT) manuals delivered in individual format have been reported to be just as effective as traditional diagnosis specific CBT manuals. We have translated and modified the "The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders" (UP-CBT) for group delivery in Mental Health Service (MHS), and shown effects comparable to traditional CBT in a naturalistic study. As the use of one manual instead of several diagnosis-specific manuals could simplify logistics, reduce waiting time, and increase therapist expertise compared to diagnosis specific CBT, we aim to test the relative efficacy of group UP-CBT and diagnosis specific group CBT.

METHODS/DESIGN: The study is a partially blinded, pragmatic, non-inferiority, parallel, multi-center randomized controlled trial (RCT) of UP-CBT vs diagnosis specific CBT for Unipolar Depression, Social Anxiety Disorder and Agoraphobia/Panic Disorder. In total, 248 patients are recruited from three regional MHS centers across Denmark and included in two intervention arms. The primary outcome is patient-ratings of well-being (WHO Well-being Index, WHO-5), secondary outcomes include level of depressive and anxious symptoms, personality variables, emotion regulation, reflective functioning, and social adjustment. Assessments are conducted before and after therapy and at 6 months follow-up. Weekly patient-rated outcomes and group evaluations are collected for every session. Outcome assessors, blind to treatment allocation, will perform the observer-based symptom ratings, and fidelity assessors will monitor manual adherence.

DISCUSSION: The current study will be the first RCT investigating the dissemination of the UP in a MHS setting, the UP delivered in groups, and with depressive patients included. Hence the results are expected to add substantially to the evidence base for rational group psychotherapy in MHS. The planned moderator and mediator analyses could spur new hypotheses about mechanisms of change in psychotherapy and the association between patient characteristics and treatment effect.

TRIAL REGISTRATION: Clinicaltrials.gov NCT02954731 . Registered 25 October 2016.

OriginalsprogEngelsk
TidsskriftBMC Psychiatry
Vol/bind17
Udgave nummer1
Sider (fra-til)37
ISSN1471-244X
DOI
StatusUdgivet - 23 jan. 2017

ID: 57568424