Transcutaneous cervical vagal nerve stimulation modulates cardiac vagal tone and tumor necrosis factor-alpha

Christina Brock, B Brock, Q Aziz, H J Møller, M Pfeiffer Jensen, Asbjorn M Drewes, Adam D Farmer

68 Citationer (Scopus)

Abstract

The vagus nerve is a central component of cholinergic anti-inflammatory pathways. We sought to evaluate the effect of bilateral transcutaneous cervical vagal nerve stimulation (t-VNS) on validated parameters of autonomic tone and cytokines in 20 healthy subjects. 24 hours after t-VNS, there was an increase in cardiac vagal tone and a reduction in tumor necrosis factor-α in comparison to baseline. No change was seen in blood pressure, cardiac sympathetic index or other cytokines. These preliminary data suggest that t-VNS exerts an autonomic and a subtle antitumor necrosis factor-α effect, which warrants further evaluation in larger controlled studies.

OriginalsprogEngelsk
TidsskriftNeurogastroenterology and Motility
Vol/bind29
Udgave nummer5
ISSN1350-1925
DOI
StatusUdgivet - maj 2017
Udgivet eksterntJa

Fingeraftryk

Dyk ned i forskningsemnerne om 'Transcutaneous cervical vagal nerve stimulation modulates cardiac vagal tone and tumor necrosis factor-alpha'. Sammen danner de et unikt fingeraftryk.

Citationsformater