Abstract
The vagus nerve is a central component of cholinergic anti-inflammatory pathways. We sought to evaluate the effect of bilateral transcutaneous cervical vagal nerve stimulation (t-VNS) on validated parameters of autonomic tone and cytokines in 20 healthy subjects. 24 hours after t-VNS, there was an increase in cardiac vagal tone and a reduction in tumor necrosis factor-α in comparison to baseline. No change was seen in blood pressure, cardiac sympathetic index or other cytokines. These preliminary data suggest that t-VNS exerts an autonomic and a subtle antitumor necrosis factor-α effect, which warrants further evaluation in larger controlled studies.
Originalsprog | Engelsk |
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Tidsskrift | Neurogastroenterology and Motility |
Vol/bind | 29 |
Udgave nummer | 5 |
ISSN | 1350-1925 |
DOI | |
Status | Udgivet - maj 2017 |
Udgivet eksternt | Ja |