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Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

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Harvard

Conti, DV, Darst, BF, Moss, LC, Saunders, EJ, Sheng, X, Chou, A, Schumacher, FR, Olama, AAA, Benlloch, S, Dadaev, T, Brook, MN, Sahimi, A, Hoffmann, TJ, Takahashi, A, Matsuda, K, Momozawa, Y, Fujita, M, Muir, K, Lophatananon, A, Wan, P, Le Marchand, L, Wilkens, LR, Stevens, VL, Gapstur, SM, Carter, BD, Schleutker, J, Tammela, TLJ, Sipeky, C, Auvinen, A, Giles, GG, Southey, MC, MacInnis, RJ, Cybulski, C, Wokołorczyk, D, Lubiński, J, Neal, DE, Donovan, JL, Hamdy, FC, Martin, RM, Nordestgaard, BG, Nielsen, SF, Weischer, M, Bojesen, SE, Røder, MA, Iversen, P, Batra, J, Chambers, S, Moya, L, Horvath, L, Clements, JA, Tilley, W, Risbridger, GP, Gronberg, H, Aly, M, Szulkin, R, Eklund, M, Nordström, T, Pashayan, N, Dunning, AM, Ghoussaini, M, Travis, RC, Key, TJ, Riboli, E, Park, JY, Sellers, TA, Lin, H-Y, Albanes, D, Weinstein, SJ, Mucci, LA, Giovannucci, E, Lindstrom, S, Kraft, P, Hunter, DJ, Penney, KL, Turman, C, Tangen, CM, Goodman, PJ, Thompson, IM, Hamilton, RJ, Fleshner, NE, Finelli, A, Parent, M-É, Stanford, JL, Ostrander, EA, Geybels, MS, Koutros, S, Freeman, LEB, Stampfer, M, Wolk, A, Håkansson, N, Andriole, GL, Hoover, RN, Machiela, MJ, Sørensen, KD, Borre, M, Blot, WJ, Zheng, W, Yeboah, ED, Mensah, JE, Lu, Y-J, Zhang, H-W, Feng, N, Mao, X, Wu, Y, Zhao, S-C, Sun, Z, Thibodeau, SN, McDonnell, SK, Schaid, DJ, West, CML, Burnet, N, Barnett, G, Maier, C, Schnoeller, T, Luedeke, M, Kibel, AS, Drake, BF, Cussenot, O, Cancel-Tassin, G, Menegaux, F, Truong, T, Koudou, YA, John, EM, Grindedal, EM, Maehle, L, Khaw, K-T, Ingles, SA, Stern, MC, Vega, A, Gómez-Caamaño, A, Fachal, L, Rosenstein, BS, Kerns, SL, Ostrer, H, Teixeira, MR, Paulo, P, Brandão, A, Watya, S, Lubwama, A, Bensen, JT, Fontham, ETH, Mohler, J, Taylor, JA, Kogevinas, M, Llorca, J, Castaño-Vinyals, G, Cannon-Albright, L, Teerlink, CC, Huff, CD, Strom, SS, Multigner, L, Blanchet, P, Brureau, L, Kaneva, R, Slavov, C, Mitev, V, Leach, RJ, Weaver, B, Brenner, H, Cuk, K, Holleczek, B, Saum, K-U, Klein, EA, Hsing, AW, Kittles, RA, Murphy, AB, Logothetis, CJ, Kim, J, Neuhausen, SL, Steele, L, Ding, YC, Isaacs, WB, Nemesure, B, Hennis, AJM, Carpten, J, Pandha, H, Michael, A, De Ruyck, K, De Meerleer, G, Ost, P, Xu, J, Razack, A, Lim, J, Teo, S-H, Newcomb, LF, Lin, DW, Fowke, JH, Neslund-Dudas, C, Rybicki, BA, Gamulin, M, Lessel, D, Kulis, T, Usmani, N, Singhal, S, Parliament, M, Claessens, F, Joniau, S, Van den Broeck, T, Gago-Dominguez, M, Castelao, JE, Martinez, ME, Larkin, S, Townsend, PA, Aukim-Hastie, C, Bush, WS, Aldrich, MC, Crawford, DC, Srivastava, S, Cullen, JC, Petrovics, G, Casey, G, Roobol, MJ, Jenster, G, van Schaik, RHN, Hu, JJ, Sanderson, M, Varma, R, McKean-Cowdin, R, Torres, M, Mancuso, N, Berndt, SI, Van Den Eeden, SK, Easton, DF, Chanock, SJ, Cook, MB, Wiklund, F, Nakagawa, H, Witte, JS, Eeles, RA, Kote-Jarai, Z & Haiman, CA 2021, 'Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction', Nature Genetics, bind 53, nr. 1, s. 65-75. https://doi.org/10.1038/s41588-020-00748-0

APA

Conti, D. V., Darst, B. F., Moss, L. C., Saunders, E. J., Sheng, X., Chou, A., Schumacher, F. R., Olama, A. A. A., Benlloch, S., Dadaev, T., Brook, M. N., Sahimi, A., Hoffmann, T. J., Takahashi, A., Matsuda, K., Momozawa, Y., Fujita, M., Muir, K., Lophatananon, A., ... Haiman, C. A. (2021). Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nature Genetics, 53(1), 65-75. https://doi.org/10.1038/s41588-020-00748-0

CBE

Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokołorczyk D, Lubiński J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin H-Y, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, Parent M-É, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu Y-J, Zhang H-W, Feng N, Mao X, Wu Y, Zhao S-C, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw K-T, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum K-U, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo S-H, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA. 2021. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nature Genetics. 53(1):65-75. https://doi.org/10.1038/s41588-020-00748-0

MLA

Vancouver

Author

Conti, David V ; Darst, Burcu F ; Moss, Lilit C ; Saunders, Edward J ; Sheng, Xin ; Chou, Alisha ; Schumacher, Fredrick R ; Olama, Ali Amin Al ; Benlloch, Sara ; Dadaev, Tokhir ; Brook, Mark N ; Sahimi, Ali ; Hoffmann, Thomas J ; Takahashi, Atushi ; Matsuda, Koichi ; Momozawa, Yukihide ; Fujita, Masashi ; Muir, Kenneth ; Lophatananon, Artitaya ; Wan, Peggy ; Le Marchand, Loic ; Wilkens, Lynne R ; Stevens, Victoria L ; Gapstur, Susan M ; Carter, Brian D ; Schleutker, Johanna ; Tammela, Teuvo L J ; Sipeky, Csilla ; Auvinen, Anssi ; Giles, Graham G ; Southey, Melissa C ; MacInnis, Robert J ; Cybulski, Cezary ; Wokołorczyk, Dominika ; Lubiński, Jan ; Neal, David E ; Donovan, Jenny L ; Hamdy, Freddie C ; Martin, Richard M ; Nordestgaard, Børge G ; Nielsen, Sune F ; Weischer, Maren ; Bojesen, Stig E ; Røder, Martin Andreas ; Iversen, Peter ; Batra, Jyotsna ; Chambers, Suzanne ; Moya, Leire ; Horvath, Lisa ; Clements, Judith A ; Tilley, Wayne ; Risbridger, Gail P ; Gronberg, Henrik ; Aly, Markus ; Szulkin, Robert ; Eklund, Martin ; Nordström, Tobias ; Pashayan, Nora ; Dunning, Alison M ; Ghoussaini, Maya ; Travis, Ruth C ; Key, Tim J ; Riboli, Elio ; Park, Jong Y ; Sellers, Thomas A ; Lin, Hui-Yi ; Albanes, Demetrius ; Weinstein, Stephanie J ; Mucci, Lorelei A ; Giovannucci, Edward ; Lindstrom, Sara ; Kraft, Peter ; Hunter, David J ; Penney, Kathryn L ; Turman, Constance ; Tangen, Catherine M ; Goodman, Phyllis J ; Thompson, Ian M ; Hamilton, Robert J ; Fleshner, Neil E ; Finelli, Antonio ; Parent, Marie-Élise ; Stanford, Janet L ; Ostrander, Elaine A ; Geybels, Milan S ; Koutros, Stella ; Freeman, Laura E Beane ; Stampfer, Meir ; Wolk, Alicja ; Håkansson, Niclas ; Andriole, Gerald L ; Hoover, Robert N ; Machiela, Mitchell J ; Sørensen, Karina Dalsgaard ; Borre, Michael ; Blot, William J ; Zheng, Wei ; Yeboah, Edward D ; Mensah, James E ; Lu, Yong-Jie ; Zhang, Hong-Wei ; Feng, Ninghan ; Mao, Xueying ; Wu, Yudong ; Zhao, Shan-Chao ; Sun, Zan ; Thibodeau, Stephen N ; McDonnell, Shannon K ; Schaid, Daniel J ; West, Catharine M L ; Burnet, Neil ; Barnett, Gill ; Maier, Christiane ; Schnoeller, Thomas ; Luedeke, Manuel ; Kibel, Adam S ; Drake, Bettina F ; Cussenot, Olivier ; Cancel-Tassin, Géraldine ; Menegaux, Florence ; Truong, Thérèse ; Koudou, Yves Akoli ; John, Esther M ; Grindedal, Eli Marie ; Maehle, Lovise ; Khaw, Kay-Tee ; Ingles, Sue A ; Stern, Mariana C ; Vega, Ana ; Gómez-Caamaño, Antonio ; Fachal, Laura ; Rosenstein, Barry S ; Kerns, Sarah L ; Ostrer, Harry ; Teixeira, Manuel R ; Paulo, Paula ; Brandão, Andreia ; Watya, Stephen ; Lubwama, Alexander ; Bensen, Jeannette T ; Fontham, Elizabeth T H ; Mohler, James ; Taylor, Jack A ; Kogevinas, Manolis ; Llorca, Javier ; Castaño-Vinyals, Gemma ; Cannon-Albright, Lisa ; Teerlink, Craig C ; Huff, Chad D ; Strom, Sara S ; Multigner, Luc ; Blanchet, Pascal ; Brureau, Laurent ; Kaneva, Radka ; Slavov, Chavdar ; Mitev, Vanio ; Leach, Robin J ; Weaver, Brandi ; Brenner, Hermann ; Cuk, Katarina ; Holleczek, Bernd ; Saum, Kai-Uwe ; Klein, Eric A ; Hsing, Ann W ; Kittles, Rick A ; Murphy, Adam B ; Logothetis, Christopher J ; Kim, Jeri ; Neuhausen, Susan L ; Steele, Linda ; Ding, Yuan Chun ; Isaacs, William B ; Nemesure, Barbara ; Hennis, Anselm J M ; Carpten, John ; Pandha, Hardev ; Michael, Agnieszka ; De Ruyck, Kim ; De Meerleer, Gert ; Ost, Piet ; Xu, Jianfeng ; Razack, Azad ; Lim, Jasmine ; Teo, Soo-Hwang ; Newcomb, Lisa F ; Lin, Daniel W ; Fowke, Jay H ; Neslund-Dudas, Christine ; Rybicki, Benjamin A ; Gamulin, Marija ; Lessel, Davor ; Kulis, Tomislav ; Usmani, Nawaid ; Singhal, Sandeep ; Parliament, Matthew ; Claessens, Frank ; Joniau, Steven ; Van den Broeck, Thomas ; Gago-Dominguez, Manuela ; Castelao, Jose Esteban ; Martinez, Maria Elena ; Larkin, Samantha ; Townsend, Paul A ; Aukim-Hastie, Claire ; Bush, William S ; Aldrich, Melinda C ; Crawford, Dana C ; Srivastava, Shiv ; Cullen, Jennifer C ; Petrovics, Gyorgy ; Casey, Graham ; Roobol, Monique J ; Jenster, Guido ; van Schaik, Ron H N ; Hu, Jennifer J ; Sanderson, Maureen ; Varma, Rohit ; McKean-Cowdin, Roberta ; Torres, Mina ; Mancuso, Nicholas ; Berndt, Sonja I ; Van Den Eeden, Stephen K ; Easton, Douglas F ; Chanock, Stephen J ; Cook, Michael B ; Wiklund, Fredrik ; Nakagawa, Hidewaki ; Witte, John S ; Eeles, Rosalind A ; Kote-Jarai, Zsofia ; Haiman, Christopher A. / Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. I: Nature Genetics. 2021 ; Bind 53, Nr. 1. s. 65-75.

Bibtex

@article{1f93fe3b1d264322867df3137460ebdc,
title = "Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction",
abstract = "Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.",
author = "Conti, {David V} and Darst, {Burcu F} and Moss, {Lilit C} and Saunders, {Edward J} and Xin Sheng and Alisha Chou and Schumacher, {Fredrick R} and Olama, {Ali Amin Al} and Sara Benlloch and Tokhir Dadaev and Brook, {Mark N} and Ali Sahimi and Hoffmann, {Thomas J} and Atushi Takahashi and Koichi Matsuda and Yukihide Momozawa and Masashi Fujita and Kenneth Muir and Artitaya Lophatananon and Peggy Wan and {Le Marchand}, Loic and Wilkens, {Lynne R} and Stevens, {Victoria L} and Gapstur, {Susan M} and Carter, {Brian D} and Johanna Schleutker and Tammela, {Teuvo L J} and Csilla Sipeky and Anssi Auvinen and Giles, {Graham G} and Southey, {Melissa C} and MacInnis, {Robert J} and Cezary Cybulski and Dominika Woko{\l}orczyk and Jan Lubi{\'n}ski and Neal, {David E} and Donovan, {Jenny L} and Hamdy, {Freddie C} and Martin, {Richard M} and Nordestgaard, {B{\o}rge G} and Nielsen, {Sune F} and Maren Weischer and Bojesen, {Stig E} and R{\o}der, {Martin Andreas} and Peter Iversen and Jyotsna Batra and Suzanne Chambers and Leire Moya and Lisa Horvath and Clements, {Judith A} and Wayne Tilley and Risbridger, {Gail P} and Henrik Gronberg and Markus Aly and Robert Szulkin and Martin Eklund and Tobias Nordstr{\"o}m and Nora Pashayan and Dunning, {Alison M} and Maya Ghoussaini and Travis, {Ruth C} and Key, {Tim J} and Elio Riboli and Park, {Jong Y} and Sellers, {Thomas A} and Hui-Yi Lin and Demetrius Albanes and Weinstein, {Stephanie J} and Mucci, {Lorelei A} and Edward Giovannucci and Sara Lindstrom and Peter Kraft and Hunter, {David J} and Penney, {Kathryn L} and Constance Turman and Tangen, {Catherine M} and Goodman, {Phyllis J} and Thompson, {Ian M} and Hamilton, {Robert J} and Fleshner, {Neil E} and Antonio Finelli and Marie-{\'E}lise Parent and Stanford, {Janet L} and Ostrander, {Elaine A} and Geybels, {Milan S} and Stella Koutros and Freeman, {Laura E Beane} and Meir Stampfer and Alicja Wolk and Niclas H{\aa}kansson and Andriole, {Gerald L} and Hoover, {Robert N} and Machiela, {Mitchell J} and S{\o}rensen, {Karina Dalsgaard} and Michael Borre and Blot, {William J} and Wei Zheng and Yeboah, {Edward D} and Mensah, {James E} and Yong-Jie Lu and Hong-Wei Zhang and Ninghan Feng and Xueying Mao and Yudong Wu and Shan-Chao Zhao and Zan Sun and Thibodeau, {Stephen N} and McDonnell, {Shannon K} and Schaid, {Daniel J} and West, {Catharine M L} and Neil Burnet and Gill Barnett and Christiane Maier and Thomas Schnoeller and Manuel Luedeke and Kibel, {Adam S} and Drake, {Bettina F} and Olivier Cussenot and G{\'e}raldine Cancel-Tassin and Florence Menegaux and Th{\'e}r{\`e}se Truong and Koudou, {Yves Akoli} and John, {Esther M} and Grindedal, {Eli Marie} and Lovise Maehle and Kay-Tee Khaw and Ingles, {Sue A} and Stern, {Mariana C} and Ana Vega and Antonio G{\'o}mez-Caama{\~n}o and Laura Fachal and Rosenstein, {Barry S} and Kerns, {Sarah L} and Harry Ostrer and Teixeira, {Manuel R} and Paula Paulo and Andreia Brand{\~a}o and Stephen Watya and Alexander Lubwama and Bensen, {Jeannette T} and Fontham, {Elizabeth T H} and James Mohler and Taylor, {Jack A} and Manolis Kogevinas and Javier Llorca and Gemma Casta{\~n}o-Vinyals and Lisa Cannon-Albright and Teerlink, {Craig C} and Huff, {Chad D} and Strom, {Sara S} and Luc Multigner and Pascal Blanchet and Laurent Brureau and Radka Kaneva and Chavdar Slavov and Vanio Mitev and Leach, {Robin J} and Brandi Weaver and Hermann Brenner and Katarina Cuk and Bernd Holleczek and Kai-Uwe Saum and Klein, {Eric A} and Hsing, {Ann W} and Kittles, {Rick A} and Murphy, {Adam B} and Logothetis, {Christopher J} and Jeri Kim and Neuhausen, {Susan L} and Linda Steele and Ding, {Yuan Chun} and Isaacs, {William B} and Barbara Nemesure and Hennis, {Anselm J M} and John Carpten and Hardev Pandha and Agnieszka Michael and {De Ruyck}, Kim and {De Meerleer}, Gert and Piet Ost and Jianfeng Xu and Azad Razack and Jasmine Lim and Soo-Hwang Teo and Newcomb, {Lisa F} and Lin, {Daniel W} and Fowke, {Jay H} and Christine Neslund-Dudas and Rybicki, {Benjamin A} and Marija Gamulin and Davor Lessel and Tomislav Kulis and Nawaid Usmani and Sandeep Singhal and Matthew Parliament and Frank Claessens and Steven Joniau and {Van den Broeck}, Thomas and Manuela Gago-Dominguez and Castelao, {Jose Esteban} and Martinez, {Maria Elena} and Samantha Larkin and Townsend, {Paul A} and Claire Aukim-Hastie and Bush, {William S} and Aldrich, {Melinda C} and Crawford, {Dana C} and Shiv Srivastava and Cullen, {Jennifer C} and Gyorgy Petrovics and Graham Casey and Roobol, {Monique J} and Guido Jenster and {van Schaik}, {Ron H N} and Hu, {Jennifer J} and Maureen Sanderson and Rohit Varma and Roberta McKean-Cowdin and Mina Torres and Nicholas Mancuso and Berndt, {Sonja I} and {Van Den Eeden}, {Stephen K} and Easton, {Douglas F} and Chanock, {Stephen J} and Cook, {Michael B} and Fredrik Wiklund and Hidewaki Nakagawa and Witte, {John S} and Eeles, {Rosalind A} and Zsofia Kote-Jarai and Haiman, {Christopher A}",
year = "2021",
month = jan,
doi = "10.1038/s41588-020-00748-0",
language = "English",
volume = "53",
pages = "65--75",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

AU - Conti, David V

AU - Darst, Burcu F

AU - Moss, Lilit C

AU - Saunders, Edward J

AU - Sheng, Xin

AU - Chou, Alisha

AU - Schumacher, Fredrick R

AU - Olama, Ali Amin Al

AU - Benlloch, Sara

AU - Dadaev, Tokhir

AU - Brook, Mark N

AU - Sahimi, Ali

AU - Hoffmann, Thomas J

AU - Takahashi, Atushi

AU - Matsuda, Koichi

AU - Momozawa, Yukihide

AU - Fujita, Masashi

AU - Muir, Kenneth

AU - Lophatananon, Artitaya

AU - Wan, Peggy

AU - Le Marchand, Loic

AU - Wilkens, Lynne R

AU - Stevens, Victoria L

AU - Gapstur, Susan M

AU - Carter, Brian D

AU - Schleutker, Johanna

AU - Tammela, Teuvo L J

AU - Sipeky, Csilla

AU - Auvinen, Anssi

AU - Giles, Graham G

AU - Southey, Melissa C

AU - MacInnis, Robert J

AU - Cybulski, Cezary

AU - Wokołorczyk, Dominika

AU - Lubiński, Jan

AU - Neal, David E

AU - Donovan, Jenny L

AU - Hamdy, Freddie C

AU - Martin, Richard M

AU - Nordestgaard, Børge G

AU - Nielsen, Sune F

AU - Weischer, Maren

AU - Bojesen, Stig E

AU - Røder, Martin Andreas

AU - Iversen, Peter

AU - Batra, Jyotsna

AU - Chambers, Suzanne

AU - Moya, Leire

AU - Horvath, Lisa

AU - Clements, Judith A

AU - Tilley, Wayne

AU - Risbridger, Gail P

AU - Gronberg, Henrik

AU - Aly, Markus

AU - Szulkin, Robert

AU - Eklund, Martin

AU - Nordström, Tobias

AU - Pashayan, Nora

AU - Dunning, Alison M

AU - Ghoussaini, Maya

AU - Travis, Ruth C

AU - Key, Tim J

AU - Riboli, Elio

AU - Park, Jong Y

AU - Sellers, Thomas A

AU - Lin, Hui-Yi

AU - Albanes, Demetrius

AU - Weinstein, Stephanie J

AU - Mucci, Lorelei A

AU - Giovannucci, Edward

AU - Lindstrom, Sara

AU - Kraft, Peter

AU - Hunter, David J

AU - Penney, Kathryn L

AU - Turman, Constance

AU - Tangen, Catherine M

AU - Goodman, Phyllis J

AU - Thompson, Ian M

AU - Hamilton, Robert J

AU - Fleshner, Neil E

AU - Finelli, Antonio

AU - Parent, Marie-Élise

AU - Stanford, Janet L

AU - Ostrander, Elaine A

AU - Geybels, Milan S

AU - Koutros, Stella

AU - Freeman, Laura E Beane

AU - Stampfer, Meir

AU - Wolk, Alicja

AU - Håkansson, Niclas

AU - Andriole, Gerald L

AU - Hoover, Robert N

AU - Machiela, Mitchell J

AU - Sørensen, Karina Dalsgaard

AU - Borre, Michael

AU - Blot, William J

AU - Zheng, Wei

AU - Yeboah, Edward D

AU - Mensah, James E

AU - Lu, Yong-Jie

AU - Zhang, Hong-Wei

AU - Feng, Ninghan

AU - Mao, Xueying

AU - Wu, Yudong

AU - Zhao, Shan-Chao

AU - Sun, Zan

AU - Thibodeau, Stephen N

AU - McDonnell, Shannon K

AU - Schaid, Daniel J

AU - West, Catharine M L

AU - Burnet, Neil

AU - Barnett, Gill

AU - Maier, Christiane

AU - Schnoeller, Thomas

AU - Luedeke, Manuel

AU - Kibel, Adam S

AU - Drake, Bettina F

AU - Cussenot, Olivier

AU - Cancel-Tassin, Géraldine

AU - Menegaux, Florence

AU - Truong, Thérèse

AU - Koudou, Yves Akoli

AU - John, Esther M

AU - Grindedal, Eli Marie

AU - Maehle, Lovise

AU - Khaw, Kay-Tee

AU - Ingles, Sue A

AU - Stern, Mariana C

AU - Vega, Ana

AU - Gómez-Caamaño, Antonio

AU - Fachal, Laura

AU - Rosenstein, Barry S

AU - Kerns, Sarah L

AU - Ostrer, Harry

AU - Teixeira, Manuel R

AU - Paulo, Paula

AU - Brandão, Andreia

AU - Watya, Stephen

AU - Lubwama, Alexander

AU - Bensen, Jeannette T

AU - Fontham, Elizabeth T H

AU - Mohler, James

AU - Taylor, Jack A

AU - Kogevinas, Manolis

AU - Llorca, Javier

AU - Castaño-Vinyals, Gemma

AU - Cannon-Albright, Lisa

AU - Teerlink, Craig C

AU - Huff, Chad D

AU - Strom, Sara S

AU - Multigner, Luc

AU - Blanchet, Pascal

AU - Brureau, Laurent

AU - Kaneva, Radka

AU - Slavov, Chavdar

AU - Mitev, Vanio

AU - Leach, Robin J

AU - Weaver, Brandi

AU - Brenner, Hermann

AU - Cuk, Katarina

AU - Holleczek, Bernd

AU - Saum, Kai-Uwe

AU - Klein, Eric A

AU - Hsing, Ann W

AU - Kittles, Rick A

AU - Murphy, Adam B

AU - Logothetis, Christopher J

AU - Kim, Jeri

AU - Neuhausen, Susan L

AU - Steele, Linda

AU - Ding, Yuan Chun

AU - Isaacs, William B

AU - Nemesure, Barbara

AU - Hennis, Anselm J M

AU - Carpten, John

AU - Pandha, Hardev

AU - Michael, Agnieszka

AU - De Ruyck, Kim

AU - De Meerleer, Gert

AU - Ost, Piet

AU - Xu, Jianfeng

AU - Razack, Azad

AU - Lim, Jasmine

AU - Teo, Soo-Hwang

AU - Newcomb, Lisa F

AU - Lin, Daniel W

AU - Fowke, Jay H

AU - Neslund-Dudas, Christine

AU - Rybicki, Benjamin A

AU - Gamulin, Marija

AU - Lessel, Davor

AU - Kulis, Tomislav

AU - Usmani, Nawaid

AU - Singhal, Sandeep

AU - Parliament, Matthew

AU - Claessens, Frank

AU - Joniau, Steven

AU - Van den Broeck, Thomas

AU - Gago-Dominguez, Manuela

AU - Castelao, Jose Esteban

AU - Martinez, Maria Elena

AU - Larkin, Samantha

AU - Townsend, Paul A

AU - Aukim-Hastie, Claire

AU - Bush, William S

AU - Aldrich, Melinda C

AU - Crawford, Dana C

AU - Srivastava, Shiv

AU - Cullen, Jennifer C

AU - Petrovics, Gyorgy

AU - Casey, Graham

AU - Roobol, Monique J

AU - Jenster, Guido

AU - van Schaik, Ron H N

AU - Hu, Jennifer J

AU - Sanderson, Maureen

AU - Varma, Rohit

AU - McKean-Cowdin, Roberta

AU - Torres, Mina

AU - Mancuso, Nicholas

AU - Berndt, Sonja I

AU - Van Den Eeden, Stephen K

AU - Easton, Douglas F

AU - Chanock, Stephen J

AU - Cook, Michael B

AU - Wiklund, Fredrik

AU - Nakagawa, Hidewaki

AU - Witte, John S

AU - Eeles, Rosalind A

AU - Kote-Jarai, Zsofia

AU - Haiman, Christopher A

PY - 2021/1

Y1 - 2021/1

N2 - Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.

AB - Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.

U2 - 10.1038/s41588-020-00748-0

DO - 10.1038/s41588-020-00748-0

M3 - Journal article

C2 - 33398198

VL - 53

SP - 65

EP - 75

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 1

ER -

ID: 62068636