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Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals

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@article{0769f2cb63e94bfdb669a71d5aeb763b,
title = "Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals",
abstract = "Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0±18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [18F]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Aggression, Female, Fluorodeoxyglucose F18, Frontal Lobe, Hormones, Humans, Impulsive Behavior, Ketanserin, Male, Middle Aged, Personality, Personality Inventory, Positron-Emission Tomography, Receptor, Serotonin, 5-HT2A, Serotonin Antagonists, Statistics, Nonparametric, Young Adult",
author = "{da Cunha-Bang}, Sofi and Stenb{\ae}k, {Dea Siggaard} and Klaus Holst and Licht, {Cecilie L{\"o}e} and Jensen, {Peter Steen} and Fr{\o}kj{\ae}r, {Vibe Geds{\o}} and Mortensen, {Erik Lykke} and Knudsen, {Gitte Moos}",
note = "Copyright {\textcopyright} 2012 Elsevier Ireland Ltd. All rights reserved.",
year = "2013",
month = may,
day = "30",
doi = "10.1016/j.pscychresns.2012.09.007",
language = "English",
volume = "212",
pages = "125--31",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Trait aggression and trait impulsivity are not related to frontal cortex 5-HT2A receptor binding in healthy individuals

AU - da Cunha-Bang, Sofi

AU - Stenbæk, Dea Siggaard

AU - Holst, Klaus

AU - Licht, Cecilie Löe

AU - Jensen, Peter Steen

AU - Frøkjær, Vibe Gedsø

AU - Mortensen, Erik Lykke

AU - Knudsen, Gitte Moos

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/5/30

Y1 - 2013/5/30

N2 - Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0±18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [18F]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals.

AB - Numerous studies indicate that the serotonergic (5-HT) transmitter system is involved in the regulation of impulsive aggression and there is from post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A receptor may be involved. We investigated 94 healthy individuals (60 men, mean age 47.0±18.7, range 23-86) to determine if trait aggression and trait impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as measured with [18F]-altanserin PET imaging. Trait aggression and trait impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted using a multiple linear regression model and internal consistency reliability of the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, results revealed no significant associations between 5-HT2AR and the AQ or BIS-11 total scores. Also, there was no significant interaction between gender and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. This is the first study to examine how 5-HT2AR relates to trait aggression and trait impulsivity in a large sample of healthy individuals. Our findings are not supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects on aggression and impulsivity in psychiatrically healthy individuals.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Aggression

KW - Female

KW - Fluorodeoxyglucose F18

KW - Frontal Lobe

KW - Hormones

KW - Humans

KW - Impulsive Behavior

KW - Ketanserin

KW - Male

KW - Middle Aged

KW - Personality

KW - Personality Inventory

KW - Positron-Emission Tomography

KW - Receptor, Serotonin, 5-HT2A

KW - Serotonin Antagonists

KW - Statistics, Nonparametric

KW - Young Adult

U2 - 10.1016/j.pscychresns.2012.09.007

DO - 10.1016/j.pscychresns.2012.09.007

M3 - Journal article

C2 - 23137806

VL - 212

SP - 125

EP - 131

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 2

ER -

ID: 42576191