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Towards selective CNS PET imaging of the 5-HT7 receptor system: Past, present and future

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@article{54d269e7efb54b88b9a905b393c497ed,
title = "Towards selective CNS PET imaging of the 5-HT7 receptor system: Past, present and future",
abstract = "Since its discovery in 1993, the serotonin receptor subtype 7 (5-HT7) has attracted significant attention as a potential drug target; due to its elucidated roles in conditions such as insomnia, schizophrenia, and more. Therefore, it is unsurprising that there has been relatively early efforts undertaken to develop a positron emission tomography (PET) imaging agent for said receptor system. PET can be clinically used to probe receptor systems in vivo, permitting information such as a drug's occupancy against this system to be investigated. This review focuses on the efforts towards the development of a 5-HT7R selective PET CNS tracer over the last 20 years, critically reflecting on applied strategies and commonly employed chemical frameworks and suggests future considerations that are needed to successfully develop a PET tracer for this clinically relevant target. This article is part of the special issue entitled 'Serotonin Research: Crossing Scales and Boundaries'.",
keywords = "5-HT7R, Molecular imaging, PET, Serotonin",
author = "L'Estrade, {Elina T} and Maria Erlandsson and Edgar, {Fraser G} and Tomas Ohlsson and Knudsen, {Gitte M} and Herth, {Matthias M}",
note = "Copyright {\textcopyright} 2019. Published by Elsevier Ltd.",
year = "2020",
month = aug,
day = "1",
doi = "10.1016/j.neuropharm.2019.107830",
language = "English",
volume = "172",
pages = "107830",
journal = "Neuropharmacology",
issn = "0028-3908",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - Towards selective CNS PET imaging of the 5-HT7 receptor system

T2 - Past, present and future

AU - L'Estrade, Elina T

AU - Erlandsson, Maria

AU - Edgar, Fraser G

AU - Ohlsson, Tomas

AU - Knudsen, Gitte M

AU - Herth, Matthias M

N1 - Copyright © 2019. Published by Elsevier Ltd.

PY - 2020/8/1

Y1 - 2020/8/1

N2 - Since its discovery in 1993, the serotonin receptor subtype 7 (5-HT7) has attracted significant attention as a potential drug target; due to its elucidated roles in conditions such as insomnia, schizophrenia, and more. Therefore, it is unsurprising that there has been relatively early efforts undertaken to develop a positron emission tomography (PET) imaging agent for said receptor system. PET can be clinically used to probe receptor systems in vivo, permitting information such as a drug's occupancy against this system to be investigated. This review focuses on the efforts towards the development of a 5-HT7R selective PET CNS tracer over the last 20 years, critically reflecting on applied strategies and commonly employed chemical frameworks and suggests future considerations that are needed to successfully develop a PET tracer for this clinically relevant target. This article is part of the special issue entitled 'Serotonin Research: Crossing Scales and Boundaries'.

AB - Since its discovery in 1993, the serotonin receptor subtype 7 (5-HT7) has attracted significant attention as a potential drug target; due to its elucidated roles in conditions such as insomnia, schizophrenia, and more. Therefore, it is unsurprising that there has been relatively early efforts undertaken to develop a positron emission tomography (PET) imaging agent for said receptor system. PET can be clinically used to probe receptor systems in vivo, permitting information such as a drug's occupancy against this system to be investigated. This review focuses on the efforts towards the development of a 5-HT7R selective PET CNS tracer over the last 20 years, critically reflecting on applied strategies and commonly employed chemical frameworks and suggests future considerations that are needed to successfully develop a PET tracer for this clinically relevant target. This article is part of the special issue entitled 'Serotonin Research: Crossing Scales and Boundaries'.

KW - 5-HT7R

KW - Molecular imaging

KW - PET

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=85075866424&partnerID=8YFLogxK

U2 - 10.1016/j.neuropharm.2019.107830

DO - 10.1016/j.neuropharm.2019.107830

M3 - Review

C2 - 31669129

VL - 172

SP - 107830

JO - Neuropharmacology

JF - Neuropharmacology

SN - 0028-3908

M1 - 107830

ER -

ID: 60966720