Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

TORS Base-of-Tongue Mucosectomy in Human Papilloma Virus-Negative Carcinoma of Unknown Primary

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Association of SLC26A4 mutations, morphology, and hearing in pendred syndrome and NSEVA

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Expert sampling of VR simulator metrics for automated assessment of mastoidectomy performance

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Laryngeal precursor lesions: Interrater and intrarater reliability of histopathological assessment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Competency-based assessment in surgeon-performed head and neck ultrasonography: A validity study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The human endolymphatic sac expresses natriuretic peptides

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Development of depression in patients with oral cavity cancer: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Chronic rhinosinusitis in COPD: A prevalent but unrecognized comorbidity impacting health related quality of life

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Face masks for the prevention of COVID-19 - Rationale and design of the randomised controlled trial DANMASK-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Association between head and neck cancer and sexually transmitted diseases: a Danish nationwide, case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Circulating tumour DNA alterations as biomarkers for head and neck cancer: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

OBJECTIVE: To analyze the role of transoral robotic base-of-tongue mucosectomy in a cohort of patients with human papilloma virus negative unknown primary carcinoma.

STUDY DESIGN: Retrospective database analysis.

METHODS: A retrospective database review from 2012 to 2018 was performed at two large tertiary centers to study patients with human papilloma virus (HPV)-negative unknown primary carcinoma who underwent transoral robotic base-of-tongue mucosectomy. P16 testing was used as a surrogate for HPV status. Patients were included that had squamous cell carcinoma metastatic to the lateral neck based on fine needle aspiration or open biopsy. Preoperatively, all patients were classified as having an unknown primary based on normal clinical and flexible endoscopic exam, normal operative endoscopy, nonlocalizing imaging, and tonsillectomy. All patients underwent robotic base-of-tongue mucosectomy. The primary outcome measure was the incidence of pathologic identification of a mucosal primary.

RESULTS: Twenty-three patients with p16-negative unknown primary carcinoma were identified and studied. All patients underwent transoral robotic base-of-tongue mucosectomy. Median age was 60 years at the time of diagnosis, and 18 of 23 (78.2%) were male. Pathologic analysis of the base-of-tongue specimens showed a primary tumor in only three of 23 (13.0%) of patients.

CONCLUSION: Despite prior evidence suggesting a high rate of primary site identification in HPV-related disease, robotic base-of-tongue mucosectomy may not be indicated for HPV-negative unknown primary carcinoma based on a low likelihood of finding the primary.

LEVEL OF EVIDENCE: 4 Laryngoscope, 2020.

OriginalsprogEngelsk
TidsskriftThe Laryngoscope
ISSN0023-852X
DOI
StatusE-pub ahead of print - 2 apr. 2020

Bibliografisk note

© 2020 The American Laryngological, Rhinological and Otological Society, Inc.

ID: 59814191