Topical morphine for oral mucositis in children: dose finding and absorption

Bettina N Nielsen; Gitte  Aagaard; Steen W Henneberg; Kjeld Schmiegelow; Palle Steen Hansen; Janne Rømsing

doi:10.1016/j.jpainsymman.2011.06.029

Topical morphine for oral mucositis in children: dose finding and absorption

Bettina N Nielsen, Gitte Aagaard, Steen W Henneberg, Kjeld Schmiegelow, Palle Steen Hansen, Janne Rømsing

22 Citationer (Scopus)

Abstract

Systemic opioids for painful chemotherapy-induced oral mucositis in children often result in unsatisfactory pain relief and a high frequency of side effects. Opioids applied topically can produce analgesia by binding to opioid receptors on peripheral terminals of sensory neurons. These receptors are upregulated during inflammation, for example, in oral mucositis.

Originalsprog	Engelsk
Tidsskrift	Journal of Pain and Symptom Management
Vol/bind	44
Udgave nummer	1
Sider (fra-til)	117-23
Antal sider	7
ISSN	0885-3924
DOI	https://doi.org/10.1016/j.jpainsymman.2011.06.029
Status	Udgivet - 2012

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10.1016/j.jpainsymman.2011.06.029

Citationsformater

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title = "Topical morphine for oral mucositis in children: dose finding and absorption",

abstract = "Systemic opioids for painful chemotherapy-induced oral mucositis in children often result in unsatisfactory pain relief and a high frequency of side effects. Opioids applied topically can produce analgesia by binding to opioid receptors on peripheral terminals of sensory neurons. These receptors are upregulated during inflammation, for example, in oral mucositis.",

author = "Nielsen, {Bettina N} and Gitte Aagaard and Henneberg, {Steen W} and Kjeld Schmiegelow and Hansen, {Palle Steen} and Janne R{\o}msing",

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T1 - Topical morphine for oral mucositis in children

T2 - dose finding and absorption

AU - Nielsen, Bettina N

AU - Aagaard, Gitte

AU - Henneberg, Steen W

AU - Schmiegelow, Kjeld

AU - Hansen, Palle Steen

AU - Rømsing, Janne

PY - 2012

Y1 - 2012

N2 - Systemic opioids for painful chemotherapy-induced oral mucositis in children often result in unsatisfactory pain relief and a high frequency of side effects. Opioids applied topically can produce analgesia by binding to opioid receptors on peripheral terminals of sensory neurons. These receptors are upregulated during inflammation, for example, in oral mucositis.

AB - Systemic opioids for painful chemotherapy-induced oral mucositis in children often result in unsatisfactory pain relief and a high frequency of side effects. Opioids applied topically can produce analgesia by binding to opioid receptors on peripheral terminals of sensory neurons. These receptors are upregulated during inflammation, for example, in oral mucositis.

U2 - 10.1016/j.jpainsymman.2011.06.029

DO - 10.1016/j.jpainsymman.2011.06.029

M3 - Journal article

C2 - 22658469

SN - 0885-3924

VL - 44

SP - 117

EP - 123

JO - Journal of Pain and Symptom Management

JF - Journal of Pain and Symptom Management

IS - 1

ER -

Topical morphine for oral mucositis in children: dose finding and absorption

Abstract

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