@article{d2bde0f3bca74518900a64446fa3d725,
title = "TOP1 gene copy numbers in colorectal cancer samples and cell lines and their association to in vitro drug sensitivity",
abstract = "A positive relationship between topoisomerase-1 (TOP1) protein and sensitivity toward the TOP1 inhibitor irinotecan has been reported in patients with metastatic colorectal cancer (mCRC). In this study, we analyzed TOP1 gene copy number variation in tumor tissue from CRC patients and CRC cell lines with different sensitivities to the TOP1 inhibitor SN-38 and oxaliplatin.",
keywords = "Camptothecin, Cell Death, Cell Line, Tumor, Cell Survival, Colorectal Neoplasms, DNA Topoisomerases, Type I, Drug Resistance, Neoplasm, Gene Dosage, Humans, In Situ Hybridization, Fluorescence, Organoplatinum Compounds, Statistics, Nonparametric",
author = "R{\o}mer, {Maria Unni Koefoed} and Jensen, {Niels Frank} and Nielsen, {Signe Lykke} and Sven M{\"u}ller and Nielsen, {Kirsten Vang} and Nielsen, {Hans J{\o}rgen} and Br{\"u}nner, {Nils Aage}",
year = "2012",
doi = "10.3109/00365521.2011.638393",
language = "English",
volume = "47",
pages = "68--79",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "1",
}