Tolerance and resistance of microbial biofilms

Oana Ciofu, Claus Moser, Peter Østrup Jensen, Niels Høiby

71 Citationer (Scopus)

Abstrakt

Chronic infections caused by microbial biofilms represent an important clinical challenge. The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major cause of persistence and clinical recurrence of these infections. In this Review, we present the extent of the clinical problem, and the mechanisms underlying the tolerance of biofilms to antibiotics and to host responses. We also explore the role of biofilms in the development of antimicrobial resistance mechanisms.

OriginalsprogEngelsk
TidsskriftNature Reviews. Microbiology
Vol/bind20
Udgave nummer10
Sider (fra-til)621-635
Antal sider15
ISSN1740-1526
DOI
StatusUdgivet - okt. 2022

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