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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Vis graf over relationer
High levels of pro-inflammatory cytokines are linked to inflammatory bowel disease (IBD). The transcription factor Caudal-related homeobox transcription factor 2 (CDX2) plays a crucial role in differentiation of intestinal epithelium and regulates IBD-susceptibility genes, including meprin 1A (MEP1A). The aim was to investigate the expression of CDX2 and MEP1A in colitis; to assess if they are regulated by tumor necrosis factor-α (TNF-α), and finally to reveal if CDX2 is involved in a TNF-α-induced down-regulation of MEP1A.
OriginalsprogEngelsk
TidsskriftB B A - Molecular Basis of Disease
Vol/bind1822
Udgave nummer6
Sider (fra-til)843-51
Antal sider9
ISSN0925-4439
DOI
StatusUdgivet - 2012

ID: 36789082