@article{34754e39f2634cc991f33048ed82bec9,
title = "TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis",
abstract = "High levels of pro-inflammatory cytokines are linked to inflammatory bowel disease (IBD). The transcription factor Caudal-related homeobox transcription factor 2 (CDX2) plays a crucial role in differentiation of intestinal epithelium and regulates IBD-susceptibility genes, including meprin 1A (MEP1A). The aim was to investigate the expression of CDX2 and MEP1A in colitis; to assess if they are regulated by tumor necrosis factor-α (TNF-α), and finally to reveal if CDX2 is involved in a TNF-α-induced down-regulation of MEP1A.",
keywords = "Adult, Animals, Antibodies, Monoclonal, Cell Line, Chromatin Immunoprecipitation, Colitis, Ulcerative, Dextran Sulfate, Female, Homeodomain Proteins, Humans, Inflammatory Bowel Diseases, Intestinal Mucosa, Male, Metalloendopeptidases, Mice, Middle Aged, RNA, Messenger, Tumor Necrosis Factor-alpha",
author = "Mehmet Coskun and Olsen, {Anders Kr{\"u}ger} and Holm, {Thomas Lindebo} and Kvist, {Peter Helding} and Nielsen, {Ole Haagen} and Riis, {Lene Buhl} and Olsen, {J{\o}rgen Lillelund} and Troelsen, {Jesper Thorvald}",
note = "{\textcopyright} 2012 Elsevier B.V. All rights reserved.",
year = "2012",
doi = "10.1016/j.bbadis.2012.01.012",
language = "English",
volume = "1822",
pages = "843--51",
journal = "Biochimica et Biophysica Acta - Molecular Basis of Disease",
issn = "0925-4439",
publisher = "Elsevier BV",
number = "6",
}