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Tissue thromboplastin induces rapid inhibition of fibrinolysis in rabbits

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We studied the fibrinolytic enzyme system in non-pregnant female New Zealand rabbits infused with rabbit brain tissue thromboplastin for 2 h and in rabbits receiving infusion of isotonic saline. The rabbits treated with thromboplastin responded with statistically significant changes in haemodynamic variables, a decrease in plasma concentration of fibrinogen (P<0.01), a decrease in platelet concentration (P<0.01), a prolongation in prothrombin time and activated partial thromboplastin time (APTT) (P<0.01), consistent with an induced intravascular coagulation. The thromboplastin infused animals had furthermore changes consistent with activation and subsequent inhibition of the fibrinolytic enzyme system. The plasminogen activity dropped continuously during the 2-h infusion (P<0.01) along with the activity of α2-antiplasmin (P<0.05). The activity of the urokinase-like plasminogen activator decreased slightly (P<0.05) during the 2-h infusion, while the factor XII-dependent plasminogen activator activity did not change. The tissue-type plasminogen activator activity decreased (P<0.01), and that of plasminogen activator inhibitor 1 (PAI-1) increased pronouncedly after 1 hour of thromboplastin infusion (P<0.01). We conclude that infusion of tissue thromboplastin causes activation of both coagulation and fibrinolysis and that tissue thromboplastin mediates a rapid inhibition of t-PA which is probably related to activation of platelets and release of PAI-1.

OriginalsprogEngelsk
TidsskriftFibrinolysis
Vol/bind10
Udgave nummer3
Sider (fra-til)143-149
Antal sider7
ISSN0268-9499
DOI
StatusUdgivet - 1996
Eksternt udgivetJa

Bibliografisk note

Funding Information:
The Department of Clinical Biochemistry, Skejby University Hospital, Aarhus, is thanked for performing the blood gas analysis and for determining the blood platelet concentration. Financial support was received from the Danish Medical Research Council and a scholarship from Aarhus County.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

ID: 66962603