Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Timing of onset of gastrointestinal bleeding in the ICU: Protocol for a preplanned observational study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Pre-operative haemodynamic monitoring and resuscitation in hip fracture patients: Protocol for a prospective observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The association between pre-operative sepsis and 30-day mortality in hip fracture patients-A cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Standardised assessment of competence in Focused Assessment with Sonography for Trauma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Haloperidol for delirium in critically ill patients - protocol for a systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Prediction of bleeding and thrombosis by standard biochemical coagulation variables in haematological intensive care patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Impact of Intraoperative Fluid Therapy and Body Temperature on Surgical Site Infection - Re-Assessment of a Randomized Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Timing of surgical site infection and pulmonary complications after laparotomy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Haloperidol for delirium in critically ill patients - protocol for a systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pulmonary artery perfusion versus no perfusion during cardiopulmonary bypass for open heart surgery in adults

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

BACKGROUND: Critically ill patients are at risk of gastrointestinal bleeding, but clinically important gastrointestinal bleeding is rare. The majority of intensive care unit (ICU) patients receive stress ulcer prophylaxis (SUP), despite uncertainty concerning the balance between benefit and harm. For approximately half of ICU patients with gastrointestinal bleeding, onset is early, ie within the first two days of the ICU stay. The aetiology of gastrointestinal bleeding and consequently the balance between benefit and harm of SUP may differ between patients with early vs late gastrointestinal bleeding.

METHODS: This is a protocol and statistical analysis plan for a preplanned exploratory substudy of the Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU) randomized clinical trial, comparing intravenous pantoprazole (40 mg once daily) with placebo in 3350 acutely ill adult ICU patients. We will describe baseline characteristics and assess the time to onset of the first clinically important episode of GI bleeding accounting for survival status and allocation to SUP or placebo. In addition, we will describe differences in therapeutic and diagnostic procedures used in patients with clinically important gastrointestinal bleeding according to early vs late bleeding and 90-day vital status.

CONCLUSIONS: The study outlined in this protocol will provide detailed information on patient characteristics and the timing of onset of gastrointestinal bleeding in the patients enrolled in the SUP-ICU trial. This may provide additional knowledge and incentives for future studies on which patients benefit from SUP.

OriginalsprogEngelsk
TidsskriftActa anaesthesiologica Scandinavica
ISSN0001-5172
DOI
StatusE-pub ahead of print - 14 maj 2018

ID: 53749390