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Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion

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Bejder, Jacob ; Andersen, Andreas Breenfeldt ; Solheim, Sara Amalie ; Gybel-Brask, Mikkel ; Secher, Niels H ; Johansson, Pär I ; Nordsborg, Nikolai Baastrup. / Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion. I: Medicine and Science in Sports and Exercise. 2019 ; Bind 51, Nr. 4. s. 692-700.

Bibtex

@article{1788abec0dd94b22821d54818e7fcef3,
title = "Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion",
abstract = "PURPOSE: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50{\%} of the red blood cells (RBC) from a standard 450-mL phlebotomy would increase mean power in a cycling time trial. In addition, the study investigated whether further ABT of RBC obtained from another 450-mL phlebotomy would increase repeated cycling sprint ability.METHODS: In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450-mL blood bags each (BT trial) or were sham phlebotomized (PLA trial). Four weeks later, a 650-kcal time trial (n = 7) was performed 3 d before and 2 h after receiving either ~50{\%} (135 mL) of the RBC or a sham transfusion. On the following day, transfusion of RBC (235 mL) from the second donation or sham transfusion was completed. A 4 × 30-s all-out cycling sprint interspersed by 4 min of recovery was performed 6 d before and 3 d after the second ABT (n = 9).RESULTS: The mean power was increased in time trials from before to after transfusion (P < 0.05) in BT (213 ± 35 vs 223 ± 38 W; mean ± SD) but not in PLA (223 ± 42 vs 224 ± 46 W). In contrast, the mean power output across the four 30-s sprint bouts remained similar in BT (639 ± 35 vs 644 ± 26 W) and PLA (638 ± 43 vs 639 ± 25 W).CONCLUSIONS: ABT of only ~135 mL of RBC is sufficient to increase mean power in a 650-kcal cycling time trial by ~5{\%} in highly trained men. In contrast, a combined high-volume transfusion of ~135 and ~235 mL of RBC does not alter 4 × 30-s all-out cycling performance interspersed with 4 min of recovery.",
keywords = "CYCLING, DOPING, ENDURANCE, INTERMITTENT EXERCISE, LARGE-VOLUME TRANSFUSION, SMALL-VOLUME TRANSFUSION, Double-Blind Method, Erythrocyte Transfusion, Blood Transfusion, Autologous, Humans, Bicycling/physiology, Male, Cross-Over Studies, Young Adult, Exercise Test, Doping in Sports/methods, Athletic Performance/physiology, Adult, Hemoglobinometry/methods",
author = "Jacob Bejder and Andersen, {Andreas Breenfeldt} and Solheim, {Sara Amalie} and Mikkel Gybel-Brask and Secher, {Niels H} and Johansson, {P{\"a}r I} and Nordsborg, {Nikolai Baastrup}",
year = "2019",
month = "4",
doi = "10.1249/MSS.0000000000001837",
language = "English",
volume = "51",
pages = "692--700",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams & Wilkins",
number = "4",

}

RIS

TY - JOUR

T1 - Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion

AU - Bejder, Jacob

AU - Andersen, Andreas Breenfeldt

AU - Solheim, Sara Amalie

AU - Gybel-Brask, Mikkel

AU - Secher, Niels H

AU - Johansson, Pär I

AU - Nordsborg, Nikolai Baastrup

PY - 2019/4

Y1 - 2019/4

N2 - PURPOSE: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBC) from a standard 450-mL phlebotomy would increase mean power in a cycling time trial. In addition, the study investigated whether further ABT of RBC obtained from another 450-mL phlebotomy would increase repeated cycling sprint ability.METHODS: In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450-mL blood bags each (BT trial) or were sham phlebotomized (PLA trial). Four weeks later, a 650-kcal time trial (n = 7) was performed 3 d before and 2 h after receiving either ~50% (135 mL) of the RBC or a sham transfusion. On the following day, transfusion of RBC (235 mL) from the second donation or sham transfusion was completed. A 4 × 30-s all-out cycling sprint interspersed by 4 min of recovery was performed 6 d before and 3 d after the second ABT (n = 9).RESULTS: The mean power was increased in time trials from before to after transfusion (P < 0.05) in BT (213 ± 35 vs 223 ± 38 W; mean ± SD) but not in PLA (223 ± 42 vs 224 ± 46 W). In contrast, the mean power output across the four 30-s sprint bouts remained similar in BT (639 ± 35 vs 644 ± 26 W) and PLA (638 ± 43 vs 639 ± 25 W).CONCLUSIONS: ABT of only ~135 mL of RBC is sufficient to increase mean power in a 650-kcal cycling time trial by ~5% in highly trained men. In contrast, a combined high-volume transfusion of ~135 and ~235 mL of RBC does not alter 4 × 30-s all-out cycling performance interspersed with 4 min of recovery.

AB - PURPOSE: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBC) from a standard 450-mL phlebotomy would increase mean power in a cycling time trial. In addition, the study investigated whether further ABT of RBC obtained from another 450-mL phlebotomy would increase repeated cycling sprint ability.METHODS: In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450-mL blood bags each (BT trial) or were sham phlebotomized (PLA trial). Four weeks later, a 650-kcal time trial (n = 7) was performed 3 d before and 2 h after receiving either ~50% (135 mL) of the RBC or a sham transfusion. On the following day, transfusion of RBC (235 mL) from the second donation or sham transfusion was completed. A 4 × 30-s all-out cycling sprint interspersed by 4 min of recovery was performed 6 d before and 3 d after the second ABT (n = 9).RESULTS: The mean power was increased in time trials from before to after transfusion (P < 0.05) in BT (213 ± 35 vs 223 ± 38 W; mean ± SD) but not in PLA (223 ± 42 vs 224 ± 46 W). In contrast, the mean power output across the four 30-s sprint bouts remained similar in BT (639 ± 35 vs 644 ± 26 W) and PLA (638 ± 43 vs 639 ± 25 W).CONCLUSIONS: ABT of only ~135 mL of RBC is sufficient to increase mean power in a 650-kcal cycling time trial by ~5% in highly trained men. In contrast, a combined high-volume transfusion of ~135 and ~235 mL of RBC does not alter 4 × 30-s all-out cycling performance interspersed with 4 min of recovery.

KW - CYCLING

KW - DOPING

KW - ENDURANCE

KW - INTERMITTENT EXERCISE

KW - LARGE-VOLUME TRANSFUSION

KW - SMALL-VOLUME TRANSFUSION

KW - Double-Blind Method

KW - Erythrocyte Transfusion

KW - Blood Transfusion, Autologous

KW - Humans

KW - Bicycling/physiology

KW - Male

KW - Cross-Over Studies

KW - Young Adult

KW - Exercise Test

KW - Doping in Sports/methods

KW - Athletic Performance/physiology

KW - Adult

KW - Hemoglobinometry/methods

U2 - 10.1249/MSS.0000000000001837

DO - 10.1249/MSS.0000000000001837

M3 - Journal article

VL - 51

SP - 692

EP - 700

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 4

ER -

ID: 56578635