Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Time to Full Enteral Feeding for Very Low-Birth-Weight Infants Varies Markedly Among Hospitals Worldwide But May Not Be Associated With Incidence of Necrotizing Enterocolitis: The NEOMUNE-NeoNutriNet Cohort Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

de Waard, M, Li, Y, Zhu, Y, Ayede, AI, Berrington, J, Bloomfield, FH, Busari, OO, Cormack, BE, Embleton, ND, van Goudoever, JB, Greisen, G, He, Z, Huang, Y, Li, X, Lin, H-C, Mei, J, Meier, PP, Nie, C, Patel, AL, Ritz, C, Sangild, PT, Skeath, T, Simmer, K, Tongo, OO, Uhlenfeldt, SS, Ye, S, Ye, X, Zhang, C & Zhou, P 2019, 'Time to Full Enteral Feeding for Very Low-Birth-Weight Infants Varies Markedly Among Hospitals Worldwide But May Not Be Associated With Incidence of Necrotizing Enterocolitis: The NEOMUNE-NeoNutriNet Cohort Study' Journal of Parenteral and Enteral Nutrition. https://doi.org/10.1002/jpen.1466

APA

CBE

de Waard M, Li Y, Zhu Y, Ayede AI, Berrington J, Bloomfield FH, Busari OO, Cormack BE, Embleton ND, van Goudoever JB, Greisen G, He Z, Huang Y, Li X, Lin H-C, Mei J, Meier PP, Nie C, Patel AL, Ritz C, Sangild PT, Skeath T, Simmer K, Tongo OO, Uhlenfeldt SS, Ye S, Ye X, Zhang C, Zhou P. 2019. Time to Full Enteral Feeding for Very Low-Birth-Weight Infants Varies Markedly Among Hospitals Worldwide But May Not Be Associated With Incidence of Necrotizing Enterocolitis: The NEOMUNE-NeoNutriNet Cohort Study. Journal of Parenteral and Enteral Nutrition. https://doi.org/10.1002/jpen.1466

MLA

Vancouver

Author

de Waard, Marita ; Li, Yanqi ; Zhu, Yanna ; Ayede, Adejumoke I ; Berrington, Janet ; Bloomfield, Frank H ; Busari, Olubunmi O ; Cormack, Barbara E ; Embleton, Nicholas D ; van Goudoever, Johannes B ; Greisen, Gorm ; He, Zhongqian ; Huang, Yan ; Li, Xiaodong ; Lin, Hung-Chih ; Mei, Jiaping ; Meier, Paula P ; Nie, Chuan ; Patel, Aloka L ; Ritz, Christian ; Sangild, Per T ; Skeath, Thomas ; Simmer, Karen ; Tongo, Olukemi O ; Uhlenfeldt, Signe S ; Ye, Sufen ; Ye, Xuqiang ; Zhang, Chunyi ; Zhou, Ping. / Time to Full Enteral Feeding for Very Low-Birth-Weight Infants Varies Markedly Among Hospitals Worldwide But May Not Be Associated With Incidence of Necrotizing Enterocolitis : The NEOMUNE-NeoNutriNet Cohort Study. I: Journal of Parenteral and Enteral Nutrition. 2019.

Bibtex

@article{3d687050ce7e44fdbee2944680e2af9c,
title = "Time to Full Enteral Feeding for Very Low-Birth-Weight Infants Varies Markedly Among Hospitals Worldwide But May Not Be Associated With Incidence of Necrotizing Enterocolitis: The NEOMUNE-NeoNutriNet Cohort Study",
abstract = "BACKGROUND: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes.METHOD: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates.RESULTS: Across NICUs, large differences were observed for time to reach full enteral feeding (TFF; 8-33 days), weight gain (5.0-14.6 g/kg/day), ∆z-scores (-0.54 to -1.64), incidence of NEC (1{\%}-13{\%}), and mortality (1{\%}-18{\%}). Adjusted for gestational age, GD units had longer TFF (26 vs 11 days), lower weight gain (8.7 vs 10.9 g/kg/day), and more days on antibiotics (17 vs 11 days; all P < .001) than non-GD units, but NEC incidence and mortality were similar.CONCLUSION: Feeding practices for VLBW infants vary markedly around the world. Use of formula and long TFF in South China was associated with more use of antibiotics and slower weight gain, but apparently not with more NEC or higher mortality. Both infant- and hospital-related factors influence feeding practices for preterm infants. Multicenter, randomized controlled trials are required to identify the optimal feeding strategy during the first weeks of life.",
author = "{de Waard}, Marita and Yanqi Li and Yanna Zhu and Ayede, {Adejumoke I} and Janet Berrington and Bloomfield, {Frank H} and Busari, {Olubunmi O} and Cormack, {Barbara E} and Embleton, {Nicholas D} and {van Goudoever}, {Johannes B} and Gorm Greisen and Zhongqian He and Yan Huang and Xiaodong Li and Hung-Chih Lin and Jiaping Mei and Meier, {Paula P} and Chuan Nie and Patel, {Aloka L} and Christian Ritz and Sangild, {Per T} and Thomas Skeath and Karen Simmer and Tongo, {Olukemi O} and Uhlenfeldt, {Signe S} and Sufen Ye and Xuqiang Ye and Chunyi Zhang and Ping Zhou",
note = "{\circledC} 2018 American Society for Parenteral and Enteral Nutrition.",
year = "2019",
doi = "10.1002/jpen.1466",
language = "English",
journal = "Journal of Parenteral and Enteral Nutrition",
issn = "0148-6071",
publisher = "Sage Science Press (US)",

}

RIS

TY - JOUR

T1 - Time to Full Enteral Feeding for Very Low-Birth-Weight Infants Varies Markedly Among Hospitals Worldwide But May Not Be Associated With Incidence of Necrotizing Enterocolitis

T2 - The NEOMUNE-NeoNutriNet Cohort Study

AU - de Waard, Marita

AU - Li, Yanqi

AU - Zhu, Yanna

AU - Ayede, Adejumoke I

AU - Berrington, Janet

AU - Bloomfield, Frank H

AU - Busari, Olubunmi O

AU - Cormack, Barbara E

AU - Embleton, Nicholas D

AU - van Goudoever, Johannes B

AU - Greisen, Gorm

AU - He, Zhongqian

AU - Huang, Yan

AU - Li, Xiaodong

AU - Lin, Hung-Chih

AU - Mei, Jiaping

AU - Meier, Paula P

AU - Nie, Chuan

AU - Patel, Aloka L

AU - Ritz, Christian

AU - Sangild, Per T

AU - Skeath, Thomas

AU - Simmer, Karen

AU - Tongo, Olukemi O

AU - Uhlenfeldt, Signe S

AU - Ye, Sufen

AU - Ye, Xuqiang

AU - Zhang, Chunyi

AU - Zhou, Ping

N1 - © 2018 American Society for Parenteral and Enteral Nutrition.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes.METHOD: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates.RESULTS: Across NICUs, large differences were observed for time to reach full enteral feeding (TFF; 8-33 days), weight gain (5.0-14.6 g/kg/day), ∆z-scores (-0.54 to -1.64), incidence of NEC (1%-13%), and mortality (1%-18%). Adjusted for gestational age, GD units had longer TFF (26 vs 11 days), lower weight gain (8.7 vs 10.9 g/kg/day), and more days on antibiotics (17 vs 11 days; all P < .001) than non-GD units, but NEC incidence and mortality were similar.CONCLUSION: Feeding practices for VLBW infants vary markedly around the world. Use of formula and long TFF in South China was associated with more use of antibiotics and slower weight gain, but apparently not with more NEC or higher mortality. Both infant- and hospital-related factors influence feeding practices for preterm infants. Multicenter, randomized controlled trials are required to identify the optimal feeding strategy during the first weeks of life.

AB - BACKGROUND: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes.METHOD: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates.RESULTS: Across NICUs, large differences were observed for time to reach full enteral feeding (TFF; 8-33 days), weight gain (5.0-14.6 g/kg/day), ∆z-scores (-0.54 to -1.64), incidence of NEC (1%-13%), and mortality (1%-18%). Adjusted for gestational age, GD units had longer TFF (26 vs 11 days), lower weight gain (8.7 vs 10.9 g/kg/day), and more days on antibiotics (17 vs 11 days; all P < .001) than non-GD units, but NEC incidence and mortality were similar.CONCLUSION: Feeding practices for VLBW infants vary markedly around the world. Use of formula and long TFF in South China was associated with more use of antibiotics and slower weight gain, but apparently not with more NEC or higher mortality. Both infant- and hospital-related factors influence feeding practices for preterm infants. Multicenter, randomized controlled trials are required to identify the optimal feeding strategy during the first weeks of life.

U2 - 10.1002/jpen.1466

DO - 10.1002/jpen.1466

M3 - Journal article

JO - Journal of Parenteral and Enteral Nutrition

JF - Journal of Parenteral and Enteral Nutrition

SN - 0148-6071

ER -

ID: 56231664