Time to consider ACE insertion/deletion genotypes and individual renoprotective treatment in diabetic nephropathy?

P K Jacobsen; L Tarnow; H-H Parving

doi:10.1038/sj.ki.5000283

Time to consider ACE insertion/deletion genotypes and individual renoprotective treatment in diabetic nephropathy?

26 Citationer (Scopus)

Abstract

One reason for the inadequacy of current renoprotective therapy and the persistent poor renal prognosis in diabetic nephropathy is the large interindividual variation in response to treatment. Genetic as well as non-genetic factors are known to influence treatment efficacy. This Commentary summarizes the impact of the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism in the ACE gene on initiation and progression of diabetic nephropathy.

Originalsprog	Engelsk
Tidsskrift	Kidney International
Vol/bind	69
Udgave nummer	8
Sider (fra-til)	1293-5
Antal sider	3
ISSN	0085-2538
DOI	https://doi.org/10.1038/sj.ki.5000283
Status	Udgivet - apr. 2006
Udgivet eksternt	Ja

Adgang til dokumentet

10.1038/sj.ki.5000283

Citationsformater

@article{2901c5fce413406a9deeafa765e379c4,

title = "Time to consider ACE insertion/deletion genotypes and individual renoprotective treatment in diabetic nephropathy?",

abstract = "One reason for the inadequacy of current renoprotective therapy and the persistent poor renal prognosis in diabetic nephropathy is the large interindividual variation in response to treatment. Genetic as well as non-genetic factors are known to influence treatment efficacy. This Commentary summarizes the impact of the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism in the ACE gene on initiation and progression of diabetic nephropathy.",

keywords = "Alleles, Angiotensin-Converting Enzyme Inhibitors, Asian Continental Ancestry Group, Diabetic Nephropathies, Gene Deletion, Genetic Variation, Genotype, Humans, Mutagenesis, Insertional, Peptidyl-Dipeptidase A, Polymorphism, Genetic, Prognosis, Survival Analysis, Comment, Journal Article",

author = "Jacobsen, {P K} and L Tarnow and H-H Parving",

year = "2006",

month = apr,

doi = "10.1038/sj.ki.5000283",

language = "English",

volume = "69",

pages = "1293--5",

journal = "Kidney International",

issn = "0085-2538",