Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Time to awakening after cardiac arrest and the association with target temperature management

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A nationwide investigation of CPR courses, books, and skill retention

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Automated external defibrillator accessibility is crucial for bystander defibrillation and survival: A registry-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Extracorporeal cardiopulmonary resuscitation for cardiac arrest: A systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Spatiotemporal AED optimization is generalizable

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Osborn waves following out-of-hospital cardiac arrest-Effect of level of temperature management and risk of arrhythmia and death

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • TTM-Trial Investigators
Vis graf over relationer

AIM: Target temperature management (TTM) at 32-36 °C is recommended in unconscious survivors of cardiac arrest. This study reports awakening in the TTM-trial. Our predefined hypotheses were that time until awakening correlates with long-term neurological outcome and is not affected by level of TTM.

METHODS: Post-hoc analysis of time until awakening after cardiac arrest, its association with long-term (180-days) neurological outcome and predictors of late awakening (day 5 or later). The trial randomized 939 comatose survivors to TTM at 33 °C or 36 °C with strict criteria for withdrawal of life-sustaining therapies. Administered sedation in the treatment groups was compared. Awakening was defined as a Glasgow Coma Scale motor score 6.

RESULTS: 496 patients had registered day of awakening in the ICU, another 43 awoke after ICU discharge. Good neurological outcome was more common in early (275/308, 89%) vs late awakening (142/188, 76%), p < 0.001. Awakening occurred later in TTM33 than in TTM36 (p = 0.002) with no difference in neurological outcome, or cumulative doses of sedative drugs at 12, 24 or 48 h. TTM33 (p = 0.006), clinical seizures (p = 0.004), and lower GCS-M on admission (p = 0.03) were independent predictors of late awakening.

CONCLUSION: Late awakening is common and often has a good neurological outcome. Time to awakening was longer in TTM33 than in TTM36, this difference could not be attributed to differences in sedative drugs administered during the first 48 h.

OriginalsprogEngelsk
TidsskriftResuscitation
Vol/bind126
Sider (fra-til)166-171
Antal sider6
ISSN0300-9572
DOI
StatusUdgivet - maj 2018

ID: 56236493