Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation

Dina Leth Møller*, Katrine Kielsen, Claus Henrik Nielsen, Henrik Sengeløv, Anders Elm Pedersen, Lars Peter Ryder, Klaus Müller

*Corresponding author af dette arbejde
1 Citationer (Scopus)

Abstract

BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity.

METHODS: We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.

RESULTS: TSLP levels rose after initiation of the conditioning to peak at day +21 after HSCT (p = .03), where TSLP levels correlated with counts of neutrophils (rho = 0.36, p = .04), monocytes (rho = 0.58, p = .006), and lymphocytes (rho = 0.59, p = .02). Overall absolute TSLP levels were not associated with acute or chronic graft-vs-host disease (a/cGvHD). However, patients mounting a sustained increase in TSLP levels at day +90 had a higher risk of cGvHD compared to patients who had returned to pre-conditioning levels at that stage (cumulative incidence: 77% vs. 38%, p = .01).

CONCLUSION: In conclusion, this study suggests a role of TSLP in immune reconstitution and alloreactivity post-HSCT. lymphopoietin (TSLP) is an immunoregulatory, Th2-polarizing cytokine produced by epithelial cells. We hypothesized that TSLP affects immune reconstitution after hematopoietic stem cell transplantation (HSCT) leading to increased alloreactivity. We measured plasma TSLP by ELISA in 38 patients and assessed the immune reconstitution by flow cytometry.

OriginalsprogEngelsk
TidsskriftImmunopharmacology and Immunotoxicology
Vol/bind44
Udgave nummer6
Sider (fra-til)1004-1012
Antal sider9
ISSN0892-3973
DOI
StatusUdgivet - dec. 2022

Fingeraftryk

Dyk ned i forskningsemnerne om 'Thymic stromal lymphopoietin levels after allogeneic hematopoietic stem cell transplantation'. Sammen danner de et unikt fingeraftryk.

Citationsformater