Three-Week Bright-Light Intervention Has Dose-Related Effects on Threat-Related Corticolimbic Reactivity and Functional Coupling

Patrick M Fisher; Martin  Korsbak Madsen; Brenda McMahon; Klaus K Holst; Sofie B Andersen; Helle R Laursen; Lis Frydenreich Hasholt; Hartwig R Siebner; Gitte M Knudsen

doi:10.1016/j.biopsych.2013.11.031

Three-Week Bright-Light Intervention Has Dose-Related Effects on Threat-Related Corticolimbic Reactivity and Functional Coupling

Patrick M Fisher, Martin Korsbak Madsen, Brenda McMahon, Klaus K Holst, Sofie B Andersen, Helle R Laursen, Lis Frydenreich Hasholt, Hartwig R Siebner, Gitte M Knudsen

38 Citationer (Scopus)

Abstract

Bright-light intervention is reported to successfully treat depression, in particular seasonal affective disorder, but the neural pathways and molecular mechanisms mediating its effects are unclear. An amygdala-prefrontal cortex corticolimbic circuit regulates responses to salient environmental stimuli (e.g., threat) and may underlie these effects. Serotonin signaling modulates this circuit and is implicated in the pathophysiology of seasonal and other affective disorders.

Originalsprog	Engelsk
Tidsskrift	Biological Psychiatry
Vol/bind	76
Sider (fra-til)	332-339
ISSN	0006-3223
DOI	https://doi.org/10.1016/j.biopsych.2013.11.031
Status	Udgivet - 2014

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10.1016/j.biopsych.2013.11.031

Citationsformater

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title = "Three-Week Bright-Light Intervention Has Dose-Related Effects on Threat-Related Corticolimbic Reactivity and Functional Coupling",

abstract = "Bright-light intervention is reported to successfully treat depression, in particular seasonal affective disorder, but the neural pathways and molecular mechanisms mediating its effects are unclear. An amygdala-prefrontal cortex corticolimbic circuit regulates responses to salient environmental stimuli (e.g., threat) and may underlie these effects. Serotonin signaling modulates this circuit and is implicated in the pathophysiology of seasonal and other affective disorders.",

author = "Fisher, {Patrick M} and {Korsbak Madsen}, Martin and Brenda McMahon and Holst, {Klaus K} and Andersen, {Sofie B} and Laursen, {Helle R} and Hasholt, {Lis Frydenreich} and Siebner, {Hartwig R} and Knudsen, {Gitte M}",

year = "2014",

doi = "10.1016/j.biopsych.2013.11.031",

language = "English",

volume = "76",

pages = "332--339",

journal = "Biological Psychiatry",

issn = "0006-3223",

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T1 - Three-Week Bright-Light Intervention Has Dose-Related Effects on Threat-Related Corticolimbic Reactivity and Functional Coupling

AU - Fisher, Patrick M

AU - Korsbak Madsen, Martin

AU - McMahon, Brenda

AU - Holst, Klaus K

AU - Andersen, Sofie B

AU - Laursen, Helle R

AU - Hasholt, Lis Frydenreich

AU - Siebner, Hartwig R

AU - Knudsen, Gitte M

PY - 2014

Y1 - 2014

N2 - Bright-light intervention is reported to successfully treat depression, in particular seasonal affective disorder, but the neural pathways and molecular mechanisms mediating its effects are unclear. An amygdala-prefrontal cortex corticolimbic circuit regulates responses to salient environmental stimuli (e.g., threat) and may underlie these effects. Serotonin signaling modulates this circuit and is implicated in the pathophysiology of seasonal and other affective disorders.

AB - Bright-light intervention is reported to successfully treat depression, in particular seasonal affective disorder, but the neural pathways and molecular mechanisms mediating its effects are unclear. An amygdala-prefrontal cortex corticolimbic circuit regulates responses to salient environmental stimuli (e.g., threat) and may underlie these effects. Serotonin signaling modulates this circuit and is implicated in the pathophysiology of seasonal and other affective disorders.

U2 - 10.1016/j.biopsych.2013.11.031

DO - 10.1016/j.biopsych.2013.11.031

M3 - Journal article

C2 - 24439303

SN - 0006-3223

VL - 76

SP - 332

EP - 339

JO - Biological Psychiatry

JF - Biological Psychiatry

ER -

Three-Week Bright-Light Intervention Has Dose-Related Effects on Threat-Related Corticolimbic Reactivity and Functional Coupling

Abstract

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