TY - JOUR
T1 - Thin or early melanoma, risk factors and associated mortality
AU - Steding-Jessen, Marianne
AU - Hölmich, Lisbet Rosenkrantz
AU - Chakera, Annette H
AU - Klausen, Siri
AU - Hovaldt, Hanna Birkbak
AU - Møller, Henrik
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2022/8/9
Y1 - 2022/8/9
N2 - INTRODUCTION: The incidence of thin and early-stage melanoma is increasing in many populations, but the clinical significance of these lesions remains partly unknown.METHODS: Firstly, melanoma deaths in Denmark (2009-2018) were followed back to establish melanoma debut in these persons. Secondly, using national registries of cancer incidence and mortality, 27,036 persons with thin or early-stage melanoma were followed-up for melanoma death.RESULTS: It is estimated that in 11% of the persons who died from melanoma, the debut was a thin or early-stage melanoma. On follow-up of persons with thin or early-stage melanoma, the 20-year risk of dying from melanoma was 3%.CONCLUSION: The absolute risk of melanoma death after a diagnosis with thin or early-stage melanoma is low. A subgroup of patients who are at a high risk may possibly be identified by a combination of stage, thickness, ulceration and dermal mitoses.FUNDING: none.TRIAL REGISTRATION: not relevant.
AB - INTRODUCTION: The incidence of thin and early-stage melanoma is increasing in many populations, but the clinical significance of these lesions remains partly unknown.METHODS: Firstly, melanoma deaths in Denmark (2009-2018) were followed back to establish melanoma debut in these persons. Secondly, using national registries of cancer incidence and mortality, 27,036 persons with thin or early-stage melanoma were followed-up for melanoma death.RESULTS: It is estimated that in 11% of the persons who died from melanoma, the debut was a thin or early-stage melanoma. On follow-up of persons with thin or early-stage melanoma, the 20-year risk of dying from melanoma was 3%.CONCLUSION: The absolute risk of melanoma death after a diagnosis with thin or early-stage melanoma is low. A subgroup of patients who are at a high risk may possibly be identified by a combination of stage, thickness, ulceration and dermal mitoses.FUNDING: none.TRIAL REGISTRATION: not relevant.
KW - Humans
KW - Incidence
KW - Melanoma
KW - Registries
KW - Risk Factors
KW - Skin Neoplasms/pathology
UR - http://www.scopus.com/inward/record.url?scp=85137214543&partnerID=8YFLogxK
M3 - Journal article
C2 - 36065888
SN - 1603-9629
VL - 69
JO - Danish Medical Journal
JF - Danish Medical Journal
IS - 9
M1 - A01220020
ER -