Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice

A Gothelf; P Hojman; Julie Gehl

doi:10.1038/gt.2010.46

Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice

A Gothelf
, P Hojman
, Julie Gehl

Afdeling for Kræftbehandling HGH

31 Citationer (Scopus)

Abstract

Gene electrotransfer refers to gene transfection by electroporation and is an effective non-viral method for delivering naked DNA into cells and tissues. This study presents data from gene electrotransfer with erythropoietin (EPO) to mouse skin. Nine-week-old female NMRI mice received one, two or three intradermal injections of 50 microg EPO plasmid and were subsequently electroporated. With plate electrodes and 100 microg of EPO, a significant increase in hemoglobin (P

Originalsprog	Engelsk
Tidsskrift	Gene Therapy (Basingstoke)
Vol/bind	17
Udgave nummer	9
Sider (fra-til)	1077-84
Antal sider	8
ISSN	0969-7128
DOI	https://doi.org/10.1038/gt.2010.46
Status	Udgivet - 1 sep. 2010

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10.1038/gt.2010.46

Citationsformater

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AB - Gene electrotransfer refers to gene transfection by electroporation and is an effective non-viral method for delivering naked DNA into cells and tissues. This study presents data from gene electrotransfer with erythropoietin (EPO) to mouse skin. Nine-week-old female NMRI mice received one, two or three intradermal injections of 50 microg EPO plasmid and were subsequently electroporated. With plate electrodes and 100 microg of EPO, a significant increase in hemoglobin (P

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Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice

Abstract

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