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Therapeutic endometrial scratching and implantation after in vitro fertilization: a multicenter randomized controlled trial

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  • Mia Steengaard Olesen
  • Benedicte Hauge
  • Lisbeth Ohrt
  • Tine Nørregaard Olesen
  • Janne Roskær
  • Vibeke Bæk
  • Helle Olesen Elbæk
  • Bugge Nøhr
  • Mette Nyegaard
  • Michael Toft Overgaard
  • Peter Humaidan
  • Axel Forman
  • Inge Agerholm
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OBJECTIVE: To study whether endometrial scratching in the luteal phase before ovarian stimulation increases clinical pregnancy rates in women with one or more previous implantation failures.

DESIGN: A nonblinded multicenter randomized clinical trial.

SETTING: Fertility clinics.

PATIENT(S): Three hundred four eligible patients scheduled for IVF/intracytoplasmic sperm injection were randomized. The intervention group (n = 151) underwent endometrial scratching in the luteal phase before controlled ovarian stimulation, while no intervention was performed in the control group (n = 153).

INTERVENTION(S): Endometrial scratching with a Pipelle de Cornier catheter in the luteal phase before ovarian stimulation.

MAIN OUTCOME MEASURE(S): Clinical pregnancy rate and prenatal and birth data.

RESULT(S): There was no overall significant improvement in clinical pregnancy rates between the control and intervention groups (38.5% vs. 44.4%; relative risk = 1.15; confidence interval [0.86-1.55]). However, subgroup analyses revealed that women with three or more previous implantation failures had a significant increase in clinical pregnancy rate (31.1% vs. 53.6%; relative risk = 1.72; confidence interval [1.05-2.83]) after scratching. No difference was seen as regards prenatal and birth data between the two groups.

CONCLUSION(S): Endometrial scratching in the luteal phase before ovarian stimulation significantly enhances the clinical pregnancy rate in women with three or more prior implantation failures. This result seems to corroborate previous reports, which found that particularly women with repeated implantation failure seem to gain a positive effect from endometrial scratching. Importantly, there were no significant differences in prenatal data and birth data between the groups.

CLINICAL TRIAL REGISTRATION NUMBER: NCT01963819.

OriginalsprogEngelsk
TidsskriftFertility and Sterility
Vol/bind112
Udgave nummer6
Sider (fra-til)1015-1021
Antal sider7
ISSN0015-0282
DOI
StatusUdgivet - dec. 2019

Bibliografisk note

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

ID: 59200007