Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism

J Sonne; H E Poulsen; S Loft; M Døssing; A Vollmer-Larsen; K Simonsen; H Thyssen; K Lundstrøm

doi:10.1007/BF00555519

Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism

J Sonne, H E Poulsen, S Loft, M Døssing, A Vollmer-Larsen, K Simonsen, H Thyssen, K Lundstrøm

Abstract

In nine healthy volunteers, the clearance and metabolism of acetaminophen 1000 mg i.v. was evaluated with and without two concomitant oral doses of codeine in order to investigate a possible interaction. Plasma acetaminophen was followed for 720 min and urine was collected for 24 h after each dose for determination of metabolites. When codeine was coadministered, the average total clearance of acetaminophen and its clearance by glucuronidation, sulphation and mercapturate formation were 0.58 to 1.12-times the control values. It is concluded that therapeutic doses of codeine do not influence the clearance or metabolism of acetaminophen.

Originalsprog	Engelsk
Tidsskrift	European Journal of Clinical Pharmacology
Vol/bind	35
Udgave nummer	1
Sider (fra-til)	109-11
Antal sider	3
ISSN	0031-6970
DOI	https://doi.org/10.1007/BF00555519
Status	Udgivet - 1988

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10.1007/BF00555519

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title = "Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism",

abstract = "In nine healthy volunteers, the clearance and metabolism of acetaminophen 1000 mg i.v. was evaluated with and without two concomitant oral doses of codeine in order to investigate a possible interaction. Plasma acetaminophen was followed for 720 min and urine was collected for 24 h after each dose for determination of metabolites. When codeine was coadministered, the average total clearance of acetaminophen and its clearance by glucuronidation, sulphation and mercapturate formation were 0.58 to 1.12-times the control values. It is concluded that therapeutic doses of codeine do not influence the clearance or metabolism of acetaminophen.",

keywords = "Acetaminophen/metabolism, Adult, Codeine/pharmacology, Drug Interactions, Female, Half-Life, Humans, Male",

author = "J Sonne and Poulsen, {H E} and S Loft and M D{\o}ssing and A Vollmer-Larsen and K Simonsen and H Thyssen and K Lundstr{\o}m",

year = "1988",

doi = "10.1007/BF00555519",

language = "English",

volume = "35",

pages = "109--11",

journal = "European Journal of Clinical Pharmacology",

issn = "0031-6970",

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TY - JOUR

T1 - Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism

AU - Sonne, J

AU - Poulsen, H E

AU - Loft, S

AU - Døssing, M

AU - Vollmer-Larsen, A

AU - Simonsen, K

AU - Thyssen, H

AU - Lundstrøm, K

PY - 1988

Y1 - 1988

N2 - In nine healthy volunteers, the clearance and metabolism of acetaminophen 1000 mg i.v. was evaluated with and without two concomitant oral doses of codeine in order to investigate a possible interaction. Plasma acetaminophen was followed for 720 min and urine was collected for 24 h after each dose for determination of metabolites. When codeine was coadministered, the average total clearance of acetaminophen and its clearance by glucuronidation, sulphation and mercapturate formation were 0.58 to 1.12-times the control values. It is concluded that therapeutic doses of codeine do not influence the clearance or metabolism of acetaminophen.

AB - In nine healthy volunteers, the clearance and metabolism of acetaminophen 1000 mg i.v. was evaluated with and without two concomitant oral doses of codeine in order to investigate a possible interaction. Plasma acetaminophen was followed for 720 min and urine was collected for 24 h after each dose for determination of metabolites. When codeine was coadministered, the average total clearance of acetaminophen and its clearance by glucuronidation, sulphation and mercapturate formation were 0.58 to 1.12-times the control values. It is concluded that therapeutic doses of codeine do not influence the clearance or metabolism of acetaminophen.

KW - Acetaminophen/metabolism

KW - Adult

KW - Codeine/pharmacology

KW - Drug Interactions

KW - Female

KW - Half-Life

KW - Humans

KW - Male

U2 - 10.1007/BF00555519

DO - 10.1007/BF00555519

M3 - Journal article

C2 - 3220092

SN - 0031-6970

VL - 35

SP - 109

EP - 111

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

IS - 1

ER -

Therapeutic doses of codeine have no effect on acetaminophen clearance or metabolism

Abstract

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