Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Theophylline enhances glucose recovery after hypoglycemia in healthy man and in type I diabetic patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes - Results from the EPICOM study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Optimering af tarmkræftscreeningen i Danmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Answer to: "Is the National Danish Colorectal Cancer Screening Programme a success?"

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Vis graf over relationer
The principal mediators of glucose counterregulation (glucagon and epinephrine) use intracellular cyclic adenosine monophosphate (cAMP) to mediate glucose release. Since theophylline increases cAMP (by inhibiting its decomposition), we investigated the effect of theophylline on glucose recovery after insulin-induced hypoglycemia. Eleven healthy subjects and nine type I (insulin-dependent) diabetic patients each participated in two experiments in randomized order, receiving on both days an insulin bolus of 0.15 IU/kg soluble insulin. On one day, theophylline (intravenous [IV] bolus of 220 mg followed by IV infusion of 1 mg/kg/h) was administered from 1 hour before induction of hypoglycemia until the end of the study period. On the other day, NaCl was administered. Plasma glucose before induction of hypoglycemia was equal on the 2 study days. The plasma glucose area under the curve (AUC) was larger with theophylline than with NaCl (P = .04 for diabetic patients and P = .003 for healthy subjects). During the most active phase of glucose counterregulation, the rate of increase of plasma glucose was larger with theophylline (P = .003 for diabetic patients and P = .03 for healthy subjects). The incremental AUC for cAMP was larger with theophylline for diabetic patients (P = .01). For healthy subjects, cAMP was greater with theophylline 30 minutes after insulin (P = .03). In conclusion, glucose recovery after hypoglycemia is significantly increased when theophylline is administered in an asthma dosage before hypoglycemia is induced. This may be due to a significant enhancement of the cAMP response.
OriginalsprogEngelsk
TidsskriftMetabolism
Vol/bind43
Udgave nummer6
Sider (fra-til)776-781
Antal sider6
ISSN0026-0495
StatusUdgivet - jun. 1994

ID: 32552425