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The External Genitalia Score (EGS): A European multicenter validation study

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Harvard

van der Straaten, S, Springer, A, Zecic, A, Hebenstreit, D, Tonnhofer, U, Gawlik, A, Baumert, M, Szeliga, K, Debulpaep, S, Desloovere, A, Tack, L, Smets, K, Wasniewska, M, Corica, D, Calafiore, M, Ljubicic, ML, Busch, AS, Juul, A, Nordenström, A, Sigurdsson, J, Flück, CE, Haamberg, T, Graf, S, Hannema, SE, Wolffenbuttel, KP, Hiort, O, Ahmed, SF & Cools, M 2020, 'The External Genitalia Score (EGS): A European multicenter validation study', The Journal of clinical endocrinology and metabolism, bind 105, nr. 3, s. E222-E230. https://doi.org/10.1210/clinem/dgz142

APA

van der Straaten, S., Springer, A., Zecic, A., Hebenstreit, D., Tonnhofer, U., Gawlik, A., Baumert, M., Szeliga, K., Debulpaep, S., Desloovere, A., Tack, L., Smets, K., Wasniewska, M., Corica, D., Calafiore, M., Ljubicic, M. L., Busch, A. S., Juul, A., Nordenström, A., ... Cools, M. (2020). The External Genitalia Score (EGS): A European multicenter validation study. The Journal of clinical endocrinology and metabolism, 105(3), E222-E230. https://doi.org/10.1210/clinem/dgz142

CBE

van der Straaten S, Springer A, Zecic A, Hebenstreit D, Tonnhofer U, Gawlik A, Baumert M, Szeliga K, Debulpaep S, Desloovere A, Tack L, Smets K, Wasniewska M, Corica D, Calafiore M, Ljubicic ML, Busch AS, Juul A, Nordenström A, Sigurdsson J, Flück CE, Haamberg T, Graf S, Hannema SE, Wolffenbuttel KP, Hiort O, Ahmed SF, Cools M. 2020. The External Genitalia Score (EGS): A European multicenter validation study. The Journal of clinical endocrinology and metabolism. 105(3):E222-E230. https://doi.org/10.1210/clinem/dgz142

MLA

Vancouver

van der Straaten S, Springer A, Zecic A, Hebenstreit D, Tonnhofer U, Gawlik A o.a. The External Genitalia Score (EGS): A European multicenter validation study. The Journal of clinical endocrinology and metabolism. 2020 mar 1;105(3):E222-E230. https://doi.org/10.1210/clinem/dgz142

Author

van der Straaten, Saskia ; Springer, Alexander ; Zecic, Aleksandra ; Hebenstreit, Doris ; Tonnhofer, Ursula ; Gawlik, Aneta ; Baumert, Malgorzata ; Szeliga, Kamila ; Debulpaep, Sara ; Desloovere, An ; Tack, Lloyd ; Smets, Koen ; Wasniewska, Malgorzata ; Corica, Domenico ; Calafiore, Mariarosa ; Ljubicic, Marie Lindhardt ; Busch, Alexander Siegfried ; Juul, Anders ; Nordenström, Anna ; Sigurdsson, Jon ; Flück, Christa E ; Haamberg, Tanja ; Graf, Stefanie ; Hannema, Sabine E ; Wolffenbuttel, Katja P ; Hiort, Olaf ; Ahmed, S Faisal ; Cools, Martine. / The External Genitalia Score (EGS) : A European multicenter validation study. I: The Journal of clinical endocrinology and metabolism. 2020 ; Bind 105, Nr. 3. s. E222-E230.

Bibtex

@article{c480957a40384aaba8aa6348d32b4d98,
title = "The External Genitalia Score (EGS): A European multicenter validation study",
abstract = "CONTEXT: Standardized description of external genitalia is needed in the assessment of children with atypical genitalia.OBJECTIVES: To validate the External Genitalia Score (EGS), to present reference values for preterm and term babies up to 24 months and correlate obtained scores with anogenital distances (AGDs).DESIGN, SETTING: A European multicenter (n = 8) validation study was conducted from July 2016 to July 2018.PATIENTS AND METHODS: EGS is based on the external masculinization score but uses a gradual scale from female to male (range, 0-12) and terminology appropriate for both sexes. The reliability of EGS and AGDs was determined by the interclass correlation coefficient (ICC). Cross-sectional data were obtained in 686 term babies (0-24 months) and 181 preterm babies, and 111 babies with atypical genitalia.RESULTS: The ICC of EGS in typical and atypical genitalia is excellent and good, respectively. Median EGS (10th to 90th centile) in males < 28 weeks gestation is 10 (8.6-11.5); in males 28-32 weeks 11.5 (9.2-12); in males 33-36 weeks 11.5 (10.5-12) and in full-term males 12 (10.5-12). In all female babies, EGS is 0 (0-0). The mean (SD) lower/upper AGD ratio (AGDl/u) is 0.45 (0.1), with significant difference between AGDl/u in males 0.49 (0.1) and females 0.39 (0.1) and intermediate values in differences of sex development (DSDs) 0.43 (0.1). The AGDl/u correlates with EGS in males with typical genitalia and in atypical genitalia.CONCLUSIONS: EGS is a reliable and valid tool to describe external genitalia in premature and term babies up to 24 months. EGS correlates with AGDl/u in males. It facilitates standardized assessment, clinical decision-making and multicenter research.",
keywords = "anogenital distances, atypical genitalia, external genitalia score, external masculinization score",
author = "{van der Straaten}, Saskia and Alexander Springer and Aleksandra Zecic and Doris Hebenstreit and Ursula Tonnhofer and Aneta Gawlik and Malgorzata Baumert and Kamila Szeliga and Sara Debulpaep and An Desloovere and Lloyd Tack and Koen Smets and Malgorzata Wasniewska and Domenico Corica and Mariarosa Calafiore and Ljubicic, {Marie Lindhardt} and Busch, {Alexander Siegfried} and Anders Juul and Anna Nordenstr{\"o}m and Jon Sigurdsson and Fl{\"u}ck, {Christa E} and Tanja Haamberg and Stefanie Graf and Hannema, {Sabine E} and Wolffenbuttel, {Katja P} and Olaf Hiort and Ahmed, {S Faisal} and Martine Cools",
note = "{\textcopyright} Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2020",
month = mar,
day = "1",
doi = "10.1210/clinem/dgz142",
language = "English",
volume = "105",
pages = "E222--E230",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",
number = "3",

}

RIS

TY - JOUR

T1 - The External Genitalia Score (EGS)

T2 - A European multicenter validation study

AU - van der Straaten, Saskia

AU - Springer, Alexander

AU - Zecic, Aleksandra

AU - Hebenstreit, Doris

AU - Tonnhofer, Ursula

AU - Gawlik, Aneta

AU - Baumert, Malgorzata

AU - Szeliga, Kamila

AU - Debulpaep, Sara

AU - Desloovere, An

AU - Tack, Lloyd

AU - Smets, Koen

AU - Wasniewska, Malgorzata

AU - Corica, Domenico

AU - Calafiore, Mariarosa

AU - Ljubicic, Marie Lindhardt

AU - Busch, Alexander Siegfried

AU - Juul, Anders

AU - Nordenström, Anna

AU - Sigurdsson, Jon

AU - Flück, Christa E

AU - Haamberg, Tanja

AU - Graf, Stefanie

AU - Hannema, Sabine E

AU - Wolffenbuttel, Katja P

AU - Hiort, Olaf

AU - Ahmed, S Faisal

AU - Cools, Martine

N1 - © Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - CONTEXT: Standardized description of external genitalia is needed in the assessment of children with atypical genitalia.OBJECTIVES: To validate the External Genitalia Score (EGS), to present reference values for preterm and term babies up to 24 months and correlate obtained scores with anogenital distances (AGDs).DESIGN, SETTING: A European multicenter (n = 8) validation study was conducted from July 2016 to July 2018.PATIENTS AND METHODS: EGS is based on the external masculinization score but uses a gradual scale from female to male (range, 0-12) and terminology appropriate for both sexes. The reliability of EGS and AGDs was determined by the interclass correlation coefficient (ICC). Cross-sectional data were obtained in 686 term babies (0-24 months) and 181 preterm babies, and 111 babies with atypical genitalia.RESULTS: The ICC of EGS in typical and atypical genitalia is excellent and good, respectively. Median EGS (10th to 90th centile) in males < 28 weeks gestation is 10 (8.6-11.5); in males 28-32 weeks 11.5 (9.2-12); in males 33-36 weeks 11.5 (10.5-12) and in full-term males 12 (10.5-12). In all female babies, EGS is 0 (0-0). The mean (SD) lower/upper AGD ratio (AGDl/u) is 0.45 (0.1), with significant difference between AGDl/u in males 0.49 (0.1) and females 0.39 (0.1) and intermediate values in differences of sex development (DSDs) 0.43 (0.1). The AGDl/u correlates with EGS in males with typical genitalia and in atypical genitalia.CONCLUSIONS: EGS is a reliable and valid tool to describe external genitalia in premature and term babies up to 24 months. EGS correlates with AGDl/u in males. It facilitates standardized assessment, clinical decision-making and multicenter research.

AB - CONTEXT: Standardized description of external genitalia is needed in the assessment of children with atypical genitalia.OBJECTIVES: To validate the External Genitalia Score (EGS), to present reference values for preterm and term babies up to 24 months and correlate obtained scores with anogenital distances (AGDs).DESIGN, SETTING: A European multicenter (n = 8) validation study was conducted from July 2016 to July 2018.PATIENTS AND METHODS: EGS is based on the external masculinization score but uses a gradual scale from female to male (range, 0-12) and terminology appropriate for both sexes. The reliability of EGS and AGDs was determined by the interclass correlation coefficient (ICC). Cross-sectional data were obtained in 686 term babies (0-24 months) and 181 preterm babies, and 111 babies with atypical genitalia.RESULTS: The ICC of EGS in typical and atypical genitalia is excellent and good, respectively. Median EGS (10th to 90th centile) in males < 28 weeks gestation is 10 (8.6-11.5); in males 28-32 weeks 11.5 (9.2-12); in males 33-36 weeks 11.5 (10.5-12) and in full-term males 12 (10.5-12). In all female babies, EGS is 0 (0-0). The mean (SD) lower/upper AGD ratio (AGDl/u) is 0.45 (0.1), with significant difference between AGDl/u in males 0.49 (0.1) and females 0.39 (0.1) and intermediate values in differences of sex development (DSDs) 0.43 (0.1). The AGDl/u correlates with EGS in males with typical genitalia and in atypical genitalia.CONCLUSIONS: EGS is a reliable and valid tool to describe external genitalia in premature and term babies up to 24 months. EGS correlates with AGDl/u in males. It facilitates standardized assessment, clinical decision-making and multicenter research.

KW - anogenital distances

KW - atypical genitalia

KW - external genitalia score

KW - external masculinization score

U2 - 10.1210/clinem/dgz142

DO - 10.1210/clinem/dgz142

M3 - Journal article

C2 - 31665438

VL - 105

SP - E222-E230

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 3

ER -

ID: 58290156