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The value of surgical staging in patients with apparent early stage epithelial ovarian carcinoma

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@article{04762636470542fd8365a845322d26c3,
title = "The value of surgical staging in patients with apparent early stage epithelial ovarian carcinoma",
abstract = "OBJECTIVE: The value of surgical staging of apparent early stage epithelial ovarian carcinoma (EOC) is unclear. The aim of this study was to evaluate the importance of surgical staging on the stage of disease and treatment plan.MATERIAL AND METHODS: All patients with apparent stage I EOC undergoing staging from 01/01/2005 to 30/06/2017 in all Danish hospitals and in the Radboud University Hospital Nijmegen, the Netherlands, were evaluated to identify the pathological findings responsible for upstaging and changes in treatment plans.RESULTS: We included 1234 patients with apparent stage I EOC. The staging steps often missed were the biopsy from the right diaphragmatic surface (missed in 96.9{\%} of all patients) and lymph node (LN) sampling or lymphadenectomy (missed in 65.5{\%} of all patients). Upstaging occurred in 393 patients (31.8{\%}) due to microscopic spread to both ovaries (0.8{\%}); ovarian surface (5.8{\%}); positive cytology (10.0{\%}); fallopian tubes (3.1{\%}), ovary (1.5{\%}) and/or uterus serosa (1.2{\%}); pelvic peritoneum (4.3{\%}); LNs (4.7{\%}); omentum (3.7{\%}); abdominal peritoneum (0.6{\%}) and right diaphragmatic surface (2.6{\%}). Of the 393 upstaged patients, 138 (35.1{\%}) had an altered treatment plan due to metastases found by surgical staging.CONCLUSION: Staging was incomplete in most patients, mainly because a biopsy of the diaphragm was omitted. However, surgical staging led to adjuvant treatment in 35.1{\%} of the upstaged patients. Peritoneal biopsies (para-colic gutters and right diaphragm) were of little value, since few patients had an adjustment of treatment plan due to these biopsies. Omitting these biopsies, in the absence of peritoneal abnormalities, is justifiable.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Biopsy/standards, Carcinoma, Ovarian Epithelial/pathology, Denmark, Female, Humans, Middle Aged, Neoplasm Staging/methods, Netherlands, Ovarian Neoplasms/pathology, Young Adult",
author = "Hengeveld, {E M} and Zusterzeel, {P L M} and H Lajer and H{\o}gdall, {C K} and M Rosendahl",
note = "Copyright {\circledC} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = "8",
doi = "10.1016/j.ygyno.2019.06.006",
language = "English",
volume = "154",
pages = "308--313",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press",
number = "2",

}

RIS

TY - JOUR

T1 - The value of surgical staging in patients with apparent early stage epithelial ovarian carcinoma

AU - Hengeveld, E M

AU - Zusterzeel, P L M

AU - Lajer, H

AU - Høgdall, C K

AU - Rosendahl, M

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/8

Y1 - 2019/8

N2 - OBJECTIVE: The value of surgical staging of apparent early stage epithelial ovarian carcinoma (EOC) is unclear. The aim of this study was to evaluate the importance of surgical staging on the stage of disease and treatment plan.MATERIAL AND METHODS: All patients with apparent stage I EOC undergoing staging from 01/01/2005 to 30/06/2017 in all Danish hospitals and in the Radboud University Hospital Nijmegen, the Netherlands, were evaluated to identify the pathological findings responsible for upstaging and changes in treatment plans.RESULTS: We included 1234 patients with apparent stage I EOC. The staging steps often missed were the biopsy from the right diaphragmatic surface (missed in 96.9% of all patients) and lymph node (LN) sampling or lymphadenectomy (missed in 65.5% of all patients). Upstaging occurred in 393 patients (31.8%) due to microscopic spread to both ovaries (0.8%); ovarian surface (5.8%); positive cytology (10.0%); fallopian tubes (3.1%), ovary (1.5%) and/or uterus serosa (1.2%); pelvic peritoneum (4.3%); LNs (4.7%); omentum (3.7%); abdominal peritoneum (0.6%) and right diaphragmatic surface (2.6%). Of the 393 upstaged patients, 138 (35.1%) had an altered treatment plan due to metastases found by surgical staging.CONCLUSION: Staging was incomplete in most patients, mainly because a biopsy of the diaphragm was omitted. However, surgical staging led to adjuvant treatment in 35.1% of the upstaged patients. Peritoneal biopsies (para-colic gutters and right diaphragm) were of little value, since few patients had an adjustment of treatment plan due to these biopsies. Omitting these biopsies, in the absence of peritoneal abnormalities, is justifiable.

AB - OBJECTIVE: The value of surgical staging of apparent early stage epithelial ovarian carcinoma (EOC) is unclear. The aim of this study was to evaluate the importance of surgical staging on the stage of disease and treatment plan.MATERIAL AND METHODS: All patients with apparent stage I EOC undergoing staging from 01/01/2005 to 30/06/2017 in all Danish hospitals and in the Radboud University Hospital Nijmegen, the Netherlands, were evaluated to identify the pathological findings responsible for upstaging and changes in treatment plans.RESULTS: We included 1234 patients with apparent stage I EOC. The staging steps often missed were the biopsy from the right diaphragmatic surface (missed in 96.9% of all patients) and lymph node (LN) sampling or lymphadenectomy (missed in 65.5% of all patients). Upstaging occurred in 393 patients (31.8%) due to microscopic spread to both ovaries (0.8%); ovarian surface (5.8%); positive cytology (10.0%); fallopian tubes (3.1%), ovary (1.5%) and/or uterus serosa (1.2%); pelvic peritoneum (4.3%); LNs (4.7%); omentum (3.7%); abdominal peritoneum (0.6%) and right diaphragmatic surface (2.6%). Of the 393 upstaged patients, 138 (35.1%) had an altered treatment plan due to metastases found by surgical staging.CONCLUSION: Staging was incomplete in most patients, mainly because a biopsy of the diaphragm was omitted. However, surgical staging led to adjuvant treatment in 35.1% of the upstaged patients. Peritoneal biopsies (para-colic gutters and right diaphragm) were of little value, since few patients had an adjustment of treatment plan due to these biopsies. Omitting these biopsies, in the absence of peritoneal abnormalities, is justifiable.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biopsy/standards

KW - Carcinoma, Ovarian Epithelial/pathology

KW - Denmark

KW - Female

KW - Humans

KW - Middle Aged

KW - Neoplasm Staging/methods

KW - Netherlands

KW - Ovarian Neoplasms/pathology

KW - Young Adult

U2 - 10.1016/j.ygyno.2019.06.006

DO - 10.1016/j.ygyno.2019.06.006

M3 - Journal article

VL - 154

SP - 308

EP - 313

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 2

ER -

ID: 59300886