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The total number of myelinated nerve fibers is reduced in corpus callosum in brains from patients with Alzheimer's disease

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  2. The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome

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  3. EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development

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  1. Quantitative Cellular Changes in the Thalamus of Patients with Multiple System Atrophy

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  2. TDP-43-specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis

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  3. Is There a Correlation Between the Number of Brain Cells and IQ?

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  4. Author Correction: Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases

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The total number of myelinated fibers in corpus callosum (CC) in Alzheimer's disease is poorly described. Using a two-dimensional fractionator principle we estimated the total number of fibers in ten females patients with Alzheimer's disease (AD) (mean age 82.8 years) and 12 female control subjects (mean age 80.6 years) and found the mean number of myelinated fibers to be significantly 30% higher in the control group (90.0 × 10 6 ; coefficient of variation = SD/mean = 27%) than in the AD group (69.3 × 10 6 ; coefficient of variation = 20%) ( p = 0.028). A significant loss of fibers (≥2.2 μm in diameter) was found in the anterior part of the CC in AD patients compared to control subjects ( p = 0.045). For both groups, we found a positive correlation between the total number of myelinated fibers and CC cross-sectional area (AD, r = 0.81; control subjects, r = 0.73). There was a negative correlation in both groups between age and total number of myelinated fibers (AD, r = −0.81; controls subjects, r = −0.59). These results implicate a loss of intrahemispheric connections in the pathophysiology of AD.
OriginalsprogEngelsk
TidsskriftNeurobiology of Aging
Vol/bind69
Sider (fra-til)58-64
Antal sider7
ISSN0197-4580
DOI
StatusUdgivet - sep. 2018

ID: 55211205