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The Top 5 Neurotransmitters from a Clinical Neurologist's Perspective

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  1. Aspects of cAMP Signaling in Epileptogenesis and Seizures and Its Potential as Drug Target

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Citrate, a Ubiquitous Key Metabolite with Regulatory Function in the CNS

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A matter of balance: role of neurexin and neuroligin at the synapse

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  4. Functional recovery of regenerating motor axons is delayed in mice heterozygously deficient for the myelin protein P(0) gene

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  1. Does continuous electroencephalography influence therapeutic decisions in neurocritical care?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Autonomic Dysfunction in Guillain-Barré Syndrome Puts Patients at Risk

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders

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Vis graf over relationer

Neurologists are proficient in neuroanatomy and -physiology but their understanding of neurochemistry tends to be mediocre. As a rule, we do not think in biochemical pathways and complex metabolic interactions but rather associate a few neurotransmitters with well-known brain diseases or drugs that we routinely prescribe. Most of us can hardly come up with more than a handful of relevant neurochemicals. From our point of view the most important neurotransmitters are, in alphabetical order, acetylcholine (associated with Alzheimer's disease and myasthenia gravis), dopamine (Parkinson's disease), glutamate and GABA (epilepsy and seizures), and serotonin (major depression; although this is arguably the domain of psychiatrists). In this commentary, the author presents the knowledge derived from neurochemistry research that has proven useful for clinical neurological practice. In addition, he explains what biochemists, basic neuroscientists and other non-neurologists need to consider in the encounter with a clinical neurologist.

OriginalsprogEngelsk
TidsskriftNeurochemical Research
Vol/bind42
Udgave nummer6
Sider (fra-til)1767-1771
ISSN0364-3190
DOI
StatusUdgivet - 2017

ID: 49883625