The T cell response to major grass allergens is regulated and includes IL-10 production in atopic but not in non-atopic subjects

A Domdey, A Liu, A Millner, K Lund, H Jacobi, H J Malling, I Søndergaard, P A Würtzen

8 Citationer (Scopus)

Abstrakt

The incidence of allergic diseases is increasing in industrialized countries and the immunological mechanisms leading to tolerance or allergy are poorly understood. Cytokines with suppressive abilities and CD4(+)CD25(+) regulatory T cells have been suggested to play a central role in allergen-specific responses. The aim was to determine whether major grass allergens induce production of suppressive cytokines in allergic and healthy subjects and to examine the inhibitory effect of these cytokines on allergic responses.
OriginalsprogEngelsk
TidsskriftInternational Archives of Allergy and Immunology
Vol/bind152
Udgave nummer3
Sider (fra-til)243-54
Antal sider12
ISSN1018-2438
DOI
StatusUdgivet - 1 jan. 2010

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