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The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren's syndrome

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Harvard

Baer, AN, McAdams DeMarco, M, Shiboski, SC, Lam, MY, Challacombe, S, Daniels, TE, Dong, Y, Greenspan, JS, Kirkham, BW, Lanfranchi, HE, Schiødt, M, Srinivasan, M, Umehara, H, Vivino, FB, Vollenweider, CF, Zhao, Y, Criswell, LA, Shiboski, CH & Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups (Steffen Ellitsgaard Hamann, members) 2015, 'The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren's syndrome', Annals of the Rheumatic Diseases, bind 74, nr. 8, s. 1557-61. https://doi.org/10.1136/annrheumdis-2014-206683

APA

Baer, A. N., McAdams DeMarco, M., Shiboski, S. C., Lam, M. Y., Challacombe, S., Daniels, T. E., Dong, Y., Greenspan, J. S., Kirkham, B. W., Lanfranchi, H. E., Schiødt, M., Srinivasan, M., Umehara, H., Vivino, F. B., Vollenweider, C. F., Zhao, Y., Criswell, L. A., Shiboski, C. H., & Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups (Steffen Ellitsgaard Hamann, members) (2015). The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren's syndrome. Annals of the Rheumatic Diseases, 74(8), 1557-61. https://doi.org/10.1136/annrheumdis-2014-206683

CBE

Baer AN, McAdams DeMarco M, Shiboski SC, Lam MY, Challacombe S, Daniels TE, Dong Y, Greenspan JS, Kirkham BW, Lanfranchi HE, Schiødt M, Srinivasan M, Umehara H, Vivino FB, Vollenweider CF, Zhao Y, Criswell LA, Shiboski CH, Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups (Steffen Ellitsgaard Hamann, members). 2015. The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren's syndrome. Annals of the Rheumatic Diseases. 74(8):1557-61. https://doi.org/10.1136/annrheumdis-2014-206683

MLA

Vancouver

Author

Baer, Alan N ; McAdams DeMarco, Mara ; Shiboski, Stephen C ; Lam, Mi Y ; Challacombe, Stephen ; Daniels, Troy E ; Dong, Yi ; Greenspan, John S ; Kirkham, Bruce W ; Lanfranchi, Hector E ; Schiødt, Morten ; Srinivasan, Muthiah ; Umehara, Hisanori ; Vivino, Frederick B ; Vollenweider, Cristina F ; Zhao, Yan ; Criswell, Lindsey A ; Shiboski, Caroline H ; Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups (Steffen Ellitsgaard Hamann, members). / The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren's syndrome. I: Annals of the Rheumatic Diseases. 2015 ; Bind 74, Nr. 8. s. 1557-61.

Bibtex

@article{5932b4d1a4624414a54452f9ff0836c9,
title = "The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sj{\"o}gren's syndrome",
abstract = "OBJECTIVE: To determine whether the Sj{\"o}gren's syndrome B (SSB)-positive/Sj{\"o}gren's syndrome A (SSA)-negative antibody profile is associated with key phenotypic features of SS.METHODS: Among registrants in the Sj{\"o}gren's International Collaborative Clinical Alliance (SICCA) with possible or established SS, we compared anti-SSA/anti-SSB reactivity profiles against concurrent phenotypic features. We fitted logistic regression models to explore the association between anti-SSA/anti-SSB reactivity profile and each key SS phenotypic feature, controlling for potential confounders.RESULTS: Among 3297 participants, 2061 (63%) had negative anti-SSA/anti-SSB, 1162 (35%) had anti-SSA with or without anti-SSB, and 74 (2%) anti-SSB alone. Key SS phenotypic features were more prevalent and had measures indicative of greater disease activity in those participants with anti-SSA, either alone or with anti-SSB, than in those with anti-SSB alone or negative SSA/SSB serology. These between-group differences were highly significant and not explained by confounding by age, race/ethnicity or gender. Participants with anti-SSB alone were comparable to those with negative SSA/SSB serology in their association with these key phenotypic features. Among SICCA participants classified with SS on the basis of the American-European Consensus Group or American College of Rheumatology criteria, only 2% required the anti-SSB-alone test result to meet these criteria.CONCLUSIONS: The presence of anti-SSB, without anti-SSA antibodies, had no significant association with SS phenotypic features, relative to seronegative participants. The solitary presence of anti-SSB antibodies does not provide any more support than negative serology for the diagnosis of SS. This serological profile should thus be interpreted cautiously in clinical practice and potentially eliminated from future classification criteria.",
author = "Baer, {Alan N} and {McAdams DeMarco}, Mara and Shiboski, {Stephen C} and Lam, {Mi Y} and Stephen Challacombe and Daniels, {Troy E} and Yi Dong and Greenspan, {John S} and Kirkham, {Bruce W} and Lanfranchi, {Hector E} and Morten Schi{\o}dt and Muthiah Srinivasan and Hisanori Umehara and Vivino, {Frederick B} and Vollenweider, {Cristina F} and Yan Zhao and Criswell, {Lindsey A} and Shiboski, {Caroline H} and {Sj{\"o}gren's International Collaborative Clinical Alliance (SICCA) Research Groups (Steffen Ellitsgaard Hamann, members)} and Hamann, {Steffen Ellitsgaard}",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",
year = "2015",
month = aug,
doi = "10.1136/annrheumdis-2014-206683",
language = "English",
volume = "74",
pages = "1557--61",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "B M J Group",
number = "8",

}

RIS

TY - JOUR

T1 - The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren's syndrome

AU - Baer, Alan N

AU - McAdams DeMarco, Mara

AU - Shiboski, Stephen C

AU - Lam, Mi Y

AU - Challacombe, Stephen

AU - Daniels, Troy E

AU - Dong, Yi

AU - Greenspan, John S

AU - Kirkham, Bruce W

AU - Lanfranchi, Hector E

AU - Schiødt, Morten

AU - Srinivasan, Muthiah

AU - Umehara, Hisanori

AU - Vivino, Frederick B

AU - Vollenweider, Cristina F

AU - Zhao, Yan

AU - Criswell, Lindsey A

AU - Shiboski, Caroline H

AU - Sjögren's International Collaborative Clinical Alliance (SICCA) Research Groups (Steffen Ellitsgaard Hamann, members)

A2 - Hamann, Steffen Ellitsgaard

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2015/8

Y1 - 2015/8

N2 - OBJECTIVE: To determine whether the Sjögren's syndrome B (SSB)-positive/Sjögren's syndrome A (SSA)-negative antibody profile is associated with key phenotypic features of SS.METHODS: Among registrants in the Sjögren's International Collaborative Clinical Alliance (SICCA) with possible or established SS, we compared anti-SSA/anti-SSB reactivity profiles against concurrent phenotypic features. We fitted logistic regression models to explore the association between anti-SSA/anti-SSB reactivity profile and each key SS phenotypic feature, controlling for potential confounders.RESULTS: Among 3297 participants, 2061 (63%) had negative anti-SSA/anti-SSB, 1162 (35%) had anti-SSA with or without anti-SSB, and 74 (2%) anti-SSB alone. Key SS phenotypic features were more prevalent and had measures indicative of greater disease activity in those participants with anti-SSA, either alone or with anti-SSB, than in those with anti-SSB alone or negative SSA/SSB serology. These between-group differences were highly significant and not explained by confounding by age, race/ethnicity or gender. Participants with anti-SSB alone were comparable to those with negative SSA/SSB serology in their association with these key phenotypic features. Among SICCA participants classified with SS on the basis of the American-European Consensus Group or American College of Rheumatology criteria, only 2% required the anti-SSB-alone test result to meet these criteria.CONCLUSIONS: The presence of anti-SSB, without anti-SSA antibodies, had no significant association with SS phenotypic features, relative to seronegative participants. The solitary presence of anti-SSB antibodies does not provide any more support than negative serology for the diagnosis of SS. This serological profile should thus be interpreted cautiously in clinical practice and potentially eliminated from future classification criteria.

AB - OBJECTIVE: To determine whether the Sjögren's syndrome B (SSB)-positive/Sjögren's syndrome A (SSA)-negative antibody profile is associated with key phenotypic features of SS.METHODS: Among registrants in the Sjögren's International Collaborative Clinical Alliance (SICCA) with possible or established SS, we compared anti-SSA/anti-SSB reactivity profiles against concurrent phenotypic features. We fitted logistic regression models to explore the association between anti-SSA/anti-SSB reactivity profile and each key SS phenotypic feature, controlling for potential confounders.RESULTS: Among 3297 participants, 2061 (63%) had negative anti-SSA/anti-SSB, 1162 (35%) had anti-SSA with or without anti-SSB, and 74 (2%) anti-SSB alone. Key SS phenotypic features were more prevalent and had measures indicative of greater disease activity in those participants with anti-SSA, either alone or with anti-SSB, than in those with anti-SSB alone or negative SSA/SSB serology. These between-group differences were highly significant and not explained by confounding by age, race/ethnicity or gender. Participants with anti-SSB alone were comparable to those with negative SSA/SSB serology in their association with these key phenotypic features. Among SICCA participants classified with SS on the basis of the American-European Consensus Group or American College of Rheumatology criteria, only 2% required the anti-SSB-alone test result to meet these criteria.CONCLUSIONS: The presence of anti-SSB, without anti-SSA antibodies, had no significant association with SS phenotypic features, relative to seronegative participants. The solitary presence of anti-SSB antibodies does not provide any more support than negative serology for the diagnosis of SS. This serological profile should thus be interpreted cautiously in clinical practice and potentially eliminated from future classification criteria.

U2 - 10.1136/annrheumdis-2014-206683

DO - 10.1136/annrheumdis-2014-206683

M3 - Journal article

C2 - 25735642

VL - 74

SP - 1557

EP - 1561

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 8

ER -

ID: 46230710