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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The single-dose pharmacokinetics of Alitretinoin and its metabolites are not significantly altered in patients with cirrhosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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Vis graf over relationer
Oral therapy with Alitretinoin (9-cis-retinoic acid, Toctino(®) ) was recently marketed for the treatment of chronic hyperkeratotic hand eczema. Since Alitretinoin is highly lipophilic and mainly metabolized in the liver, it is currently considered to be contraindicated in patients with liver disease. However, the pharmacokinetics and metabolism of Alitretinoin have not yet been studied in these patients.
OriginalsprogEngelsk
TidsskriftBritish Journal of Dermatology
Vol/bind170
Udgave nummer2
Sider (fra-til)408-14
Antal sider7
ISSN0007-0963
DOI
StatusUdgivet - feb. 2014

ID: 39947617