The single-dose pharmacokinetics of Alitretinoin and its metabolites are not significantly altered in patients with cirrhosis

J P Thyssen; L Vester; C Grønhøj Larsen; K Smidt; P Jakobsen; S H Hansen; D Vind-Kezunovic; L L Gluud; F Grønhøj Larsen

doi:10.1111/bjd.12546

The single-dose pharmacokinetics of Alitretinoin and its metabolites are not significantly altered in patients with cirrhosis

J P Thyssen, L Vester, C Grønhøj Larsen, K Smidt, P Jakobsen, S H Hansen, D Vind-Kezunovic, L L Gluud, F Grønhøj Larsen

3 Citationer (Scopus)

Abstract

Oral therapy with Alitretinoin (9-cis-retinoic acid, Toctino(®) ) was recently marketed for the treatment of chronic hyperkeratotic hand eczema. Since Alitretinoin is highly lipophilic and mainly metabolized in the liver, it is currently considered to be contraindicated in patients with liver disease. However, the pharmacokinetics and metabolism of Alitretinoin have not yet been studied in these patients.

Originalsprog	Engelsk
Tidsskrift	British Journal of Dermatology
Vol/bind	170
Udgave nummer	2
Sider (fra-til)	408-14
Antal sider	7
ISSN	0007-0963
DOI	https://doi.org/10.1111/bjd.12546
Status	Udgivet - feb. 2014

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10.1111/bjd.12546

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@article{c36c994b324e4469937afe2eb38f495d,

title = "The single-dose pharmacokinetics of Alitretinoin and its metabolites are not significantly altered in patients with cirrhosis",

abstract = "Oral therapy with Alitretinoin (9-cis-retinoic acid, Toctino({\textregistered}) ) was recently marketed for the treatment of chronic hyperkeratotic hand eczema. Since Alitretinoin is highly lipophilic and mainly metabolized in the liver, it is currently considered to be contraindicated in patients with liver disease. However, the pharmacokinetics and metabolism of Alitretinoin have not yet been studied in these patients.",

author = "Thyssen, {J P} and L Vester and {Gr{\o}nh{\o}j Larsen}, C and K Smidt and P Jakobsen and Hansen, {S H} and D Vind-Kezunovic and Gluud, {L L} and Larsen, {F Gr{\o}nh{\o}j}",

year = "2014",

month = feb,

doi = "10.1111/bjd.12546",

language = "English",

volume = "170",

pages = "408--14",

journal = "British Journal of Dermatology",

issn = "0007-0963",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

TY - JOUR

T1 - The single-dose pharmacokinetics of Alitretinoin and its metabolites are not significantly altered in patients with cirrhosis

AU - Thyssen, J P

AU - Vester, L

AU - Grønhøj Larsen, C

AU - Smidt, K

AU - Jakobsen, P

AU - Hansen, S H

AU - Vind-Kezunovic, D

AU - Gluud, L L

AU - Larsen, F Grønhøj

PY - 2014/2

Y1 - 2014/2

N2 - Oral therapy with Alitretinoin (9-cis-retinoic acid, Toctino(®) ) was recently marketed for the treatment of chronic hyperkeratotic hand eczema. Since Alitretinoin is highly lipophilic and mainly metabolized in the liver, it is currently considered to be contraindicated in patients with liver disease. However, the pharmacokinetics and metabolism of Alitretinoin have not yet been studied in these patients.

AB - Oral therapy with Alitretinoin (9-cis-retinoic acid, Toctino(®) ) was recently marketed for the treatment of chronic hyperkeratotic hand eczema. Since Alitretinoin is highly lipophilic and mainly metabolized in the liver, it is currently considered to be contraindicated in patients with liver disease. However, the pharmacokinetics and metabolism of Alitretinoin have not yet been studied in these patients.

U2 - 10.1111/bjd.12546

DO - 10.1111/bjd.12546

M3 - Journal article

C2 - 23909409

SN - 0007-0963

VL - 170

SP - 408

EP - 414

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 2

ER -

The single-dose pharmacokinetics of Alitretinoin and its metabolites are not significantly altered in patients with cirrhosis

Abstract

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