The significance of mitochondrial haplogroups in preeclampsia risk

Kristina Wendelboe Olsen, Paula L Hedley, Christian M Hagen, Line Rode, Sophie Placing, Karen R Wøjdemann, Anne-Cathrine Shalmi, Karin Sundberg, Anne Nørremølle, Ann Tabor, Joanna L Elson*, Michael Christiansen

*Corresponding author af dette arbejde


OBJECTIVE: To determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.

METHODS: This retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.

RESULTS: No significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.

CONCLUSION: Mitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.

TidsskriftPregnancy Hypertension
Sider (fra-til)146-151
Antal sider6
StatusUdgivet - 2023


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