The separate and combined impact of the intestinal hormones, GIP, GLP-1 and GLP-2, on glucagon secretion in type 2 diabetes

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    Abstract

    Type 2 diabetes mellitus (T2DM) is associated with reduced suppression of glucagon during oral glucose tolerance test (OGTT) whereas isoglycemic intravenous (iv) glucose infusion (IIGI) results in normal glucagon suppression in these patients. We examined the role of the intestinal hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) in this discrepancy. Glucagon responses were measured during a 3-hour 50 g-OGTT (day A) and an IIGI (day B) in 10 patients with T2DM (age (mean±SEM): 51±3 years; body mass index: 33±2 kg/m(2); Hb A(1c): 6.5±0.2%). During four additional IIGIs, GIP (day C), GLP-1 (day D), GLP-2 (day E) and a combination of the three (day F), respectively, were infused intravenously. Isoglycemia during all six study days was obtained. As expected, no suppression of glucagon occurred during the initial phase of the OGTT, whereas significant (P
    OriginalsprogEngelsk
    TidsskriftAmerican Journal of Physiology: Endocrinology and Metabolism
    Vol/bind300
    Udgave nummer6
    Sider (fra-til)E1038-E1046
    ISSN0193-1849
    DOI
    StatusUdgivet - 8 mar. 2011

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