Abstract
Type 2 diabetes mellitus (T2DM) is associated with reduced suppression of glucagon during oral glucose tolerance test (OGTT) whereas isoglycemic intravenous (iv) glucose infusion (IIGI) results in normal glucagon suppression in these patients. We examined the role of the intestinal hormones glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) in this discrepancy. Glucagon responses were measured during a 3-hour 50 g-OGTT (day A) and an IIGI (day B) in 10 patients with T2DM (age (mean±SEM): 51±3 years; body mass index: 33±2 kg/m(2); Hb A(1c): 6.5±0.2%). During four additional IIGIs, GIP (day C), GLP-1 (day D), GLP-2 (day E) and a combination of the three (day F), respectively, were infused intravenously. Isoglycemia during all six study days was obtained. As expected, no suppression of glucagon occurred during the initial phase of the OGTT, whereas significant (P
Originalsprog | Engelsk |
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Tidsskrift | American Journal of Physiology: Endocrinology and Metabolism |
Vol/bind | 300 |
Udgave nummer | 6 |
Sider (fra-til) | E1038-E1046 |
ISSN | 0193-1849 |
DOI | |
Status | Udgivet - 8 mar. 2011 |