Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The Self in the Spectrum: A Meta-analysis of the Evidence Linking Basic Self-Disorders and Schizophrenia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A Nationwide Cohort Study of Nonrandom Mating in Schizophrenia and Bipolar Disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Obsessive-Compulsive Symptoms and Other Symptoms of the At-risk Mental State for Psychosis: A Network Perspective

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Symptom Remission and Brain Cortical Networks at First Clinical Presentation of Psychosis: The OPTiMiSE Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. "Transition" to Schizophrenia or Fluctuations within the Same Disorder?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Formal Thought Disorder and Self-Disorder: An Empirical Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Exploring schizophrenia spectrum psychopathology in borderline personality disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Disturbed self-experience has been reported as a characteristic feature of schizophrenia since the first formulation of its diagnostic concept; however, only in the last 2 decades an explicit notion of basic Self-disturbance, or Self-Disorders (SD), has emerged as target for a systematic research program. We conducted systematic searches in bibliographical databases to identify cross-sectional studies that explored SD across different diagnostic groups and explored diagnostic ascription within or outside schizophrenia spectrum disorders (SSD) as main outcome. Data were pooled using fixed- and random-effects meta-analysis models. Heterogeneity was assessed using stratified meta-analyses and meta-regression. Of 218 identified studies, 32 were included in the systematic review and 27 in the meta-analysis. Patients diagnosed with SSD scored higher on measures of SD than healthy controls (HC) (Hedges' g = 1.8; 95% CI = 1.5 to 2.0), individuals diagnosed with other mental illness (OMI) (1.9; 1.6 to 2.2), bipolar or affective disorders (1.8; 1.4 to 2.2), and clinical high risk for psychosis (CHR) (1.6; 0.9 to 2.4). Patients with schizotypy or schizotypal personality disorder scored higher on measures of SD than OMI (1.5; 1.3 to 1.8) and HC (1.4; 1.1 to 1.7). Patients with first-episode psychosis scored higher on measures of SD than HC (2.5; 2.1 to 2.9) and OMI (1.6; 1.2 to 2.1). Subjects at CHR scored higher on measures of SD than HC (2.0; 1.7 to 2.2) and OMI (19; 1.6 to 2.2). Overall, heterogeneity ranged from negligible to high, especially in comparisons of the target group with OMI, probably as a reflection of the immanent diagnostic heterogeneity of this group. The findings suggest that SD selectively aggregate within schizophrenia spectrum disorders as compared to other mental disorders and that they could be a central phenotypic marker of vulnerability to schizophrenia across the different shades of severity of its spectrum of disorders.

OriginalsprogEngelsk
TidsskriftSchizophrenia Bulletin
Vol/bind47
Udgave nummer4
Sider (fra-til)1007-1017
Antal sider11
ISSN0586-7614
DOI
StatusUdgivet - 1 jul. 2021

ID: 67570890