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The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia

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Northoff, Georg ; Sandsten, Karl Erik ; Nordgaard, Julie ; Kjaer, Troels Wesenberg ; Parnas, Josef. / The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia. I: Schizophrenia Bulletin. 2021 ; Bind 47, Nr. 1. s. 170-179.

Bibtex

@article{1540a1e8e61b4091a6ea1545fb0ee694,
title = "The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia",
abstract = "Schizophrenia (SCZ) can be characterized as a basic self-disorder that is featured by abnormal temporal integration on phenomenological (experience) and psychological (information processing) levels. Temporal integration on the neuronal level can be measured by the brain's intrinsic neural timescale using the autocorrelation window (ACW) and power-law exponent (PLE). Our goal was to relate intrinsic neural timescales (ACW, PLE), as a proxy of temporal integration on the neuronal level, to temporal integration related to self-disorder on psychological (Enfacement illusion task in electroencephalography) and phenomenological (Examination of Anomalous Self-Experience [EASE]) levels. SCZ participants exhibited prolonged ACW and higher PLE during the self-referential task (Enfacement illusion), but not during the non-self-referential task (auditory oddball). The degree of ACW/PLE change during task relative to rest was significantly reduced in self-referential task in SCZ. A moderation model showed that low and high ACW/PLE exerted differential impact on the relationship of self-disorder (EASE) and negative symptoms (PANSS). In sum, we demonstrate abnormal prolongation in intrinsic neural timescale during self-reference in SCZ including its relation to basic self-disorder and negative symptoms. Our results point to abnormal relation of self and temporal integration at the core of SCZ constituting a {"}common currency{"} of neuronal, psychological, and phenomenological levels.",
keywords = "auto-correlation window, EASE, EEG, enfacement illusion, intrinsic neural timescale, power law exponent, rest-task modulation, self-disorder",
author = "Georg Northoff and Sandsten, {Karl Erik} and Julie Nordgaard and Kjaer, {Troels Wesenberg} and Josef Parnas",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2021",
month = jan,
day = "23",
doi = "10.1093/schbul/sbaa083",
language = "English",
volume = "47",
pages = "170--179",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia

AU - Northoff, Georg

AU - Sandsten, Karl Erik

AU - Nordgaard, Julie

AU - Kjaer, Troels Wesenberg

AU - Parnas, Josef

N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2021/1/23

Y1 - 2021/1/23

N2 - Schizophrenia (SCZ) can be characterized as a basic self-disorder that is featured by abnormal temporal integration on phenomenological (experience) and psychological (information processing) levels. Temporal integration on the neuronal level can be measured by the brain's intrinsic neural timescale using the autocorrelation window (ACW) and power-law exponent (PLE). Our goal was to relate intrinsic neural timescales (ACW, PLE), as a proxy of temporal integration on the neuronal level, to temporal integration related to self-disorder on psychological (Enfacement illusion task in electroencephalography) and phenomenological (Examination of Anomalous Self-Experience [EASE]) levels. SCZ participants exhibited prolonged ACW and higher PLE during the self-referential task (Enfacement illusion), but not during the non-self-referential task (auditory oddball). The degree of ACW/PLE change during task relative to rest was significantly reduced in self-referential task in SCZ. A moderation model showed that low and high ACW/PLE exerted differential impact on the relationship of self-disorder (EASE) and negative symptoms (PANSS). In sum, we demonstrate abnormal prolongation in intrinsic neural timescale during self-reference in SCZ including its relation to basic self-disorder and negative symptoms. Our results point to abnormal relation of self and temporal integration at the core of SCZ constituting a "common currency" of neuronal, psychological, and phenomenological levels.

AB - Schizophrenia (SCZ) can be characterized as a basic self-disorder that is featured by abnormal temporal integration on phenomenological (experience) and psychological (information processing) levels. Temporal integration on the neuronal level can be measured by the brain's intrinsic neural timescale using the autocorrelation window (ACW) and power-law exponent (PLE). Our goal was to relate intrinsic neural timescales (ACW, PLE), as a proxy of temporal integration on the neuronal level, to temporal integration related to self-disorder on psychological (Enfacement illusion task in electroencephalography) and phenomenological (Examination of Anomalous Self-Experience [EASE]) levels. SCZ participants exhibited prolonged ACW and higher PLE during the self-referential task (Enfacement illusion), but not during the non-self-referential task (auditory oddball). The degree of ACW/PLE change during task relative to rest was significantly reduced in self-referential task in SCZ. A moderation model showed that low and high ACW/PLE exerted differential impact on the relationship of self-disorder (EASE) and negative symptoms (PANSS). In sum, we demonstrate abnormal prolongation in intrinsic neural timescale during self-reference in SCZ including its relation to basic self-disorder and negative symptoms. Our results point to abnormal relation of self and temporal integration at the core of SCZ constituting a "common currency" of neuronal, psychological, and phenomenological levels.

KW - auto-correlation window

KW - EASE

KW - EEG

KW - enfacement illusion

KW - intrinsic neural timescale

KW - power law exponent

KW - rest-task modulation

KW - self-disorder

UR - http://www.scopus.com/inward/record.url?scp=85100360580&partnerID=8YFLogxK

U2 - 10.1093/schbul/sbaa083

DO - 10.1093/schbul/sbaa083

M3 - Journal article

C2 - 32614395

VL - 47

SP - 170

EP - 179

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 1

ER -

ID: 60329128