Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Association Between Childhood Green Space, Genetic Liability, and the Incidence of Schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Emotion Recognition and Adverse Childhood Experiences in Individuals at Clinical High Risk of Psychosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Electrocardiogram Characteristics and Their Association With Psychotropic Drugs Among Patients With Schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Identifying Schizo-Obsessive Comorbidity by Tract-Based Spatial Statistics and Probabilistic Tractography

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Stability of admission diagnoses; data from a specialized in-patient treatment facility for dual diagnosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Exploring schizophrenia spectrum psychopathology in borderline personality disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Schizophrenia-spectrum psychopathology in obsessive-compulsive disorder: an empirical study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Differentialdiagnostik ved tvangsfænomener

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Altered self-recognition in schizophrenia - A reply to critics

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Vis graf over relationer

Schizophrenia (SCZ) can be characterized as a basic self-disorder that is featured by abnormal temporal integration on phenomenological (experience) and psychological (information processing) levels. Temporal integration on the neuronal level can be measured by the brain's intrinsic neural timescale using the autocorrelation window (ACW) and power-law exponent (PLE). Our goal was to relate intrinsic neural timescales (ACW, PLE), as a proxy of temporal integration on the neuronal level, to temporal integration related to self-disorder on psychological (Enfacement illusion task in electroencephalography) and phenomenological (Examination of Anomalous Self-Experience [EASE]) levels. SCZ participants exhibited prolonged ACW and higher PLE during the self-referential task (Enfacement illusion), but not during the non-self-referential task (auditory oddball). The degree of ACW/PLE change during task relative to rest was significantly reduced in self-referential task in SCZ. A moderation model showed that low and high ACW/PLE exerted differential impact on the relationship of self-disorder (EASE) and negative symptoms (PANSS). In sum, we demonstrate abnormal prolongation in intrinsic neural timescale during self-reference in SCZ including its relation to basic self-disorder and negative symptoms. Our results point to abnormal relation of self and temporal integration at the core of SCZ constituting a "common currency" of neuronal, psychological, and phenomenological levels.

OriginalsprogEngelsk
TidsskriftSchizophrenia Bulletin
Vol/bind47
Udgave nummer1
Sider (fra-til)170-179
Antal sider10
ISSN0586-7614
DOI
StatusUdgivet - 23 jan. 2021

Bibliografisk note

© The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

ID: 60329128