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Region Hovedstaden - en del af Københavns Universitetshospital

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: Conceptual framework and therapeutic potential

Publikation: Bidrag til tidsskriftReviewForskningpeer review


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  • Jean-Charles Fruchart
  • Raul D Santos
  • Carlos Aguilar-Salinas
  • Masanori Aikawa
  • Khalid Al Rasadi
  • Pierre Amarenco
  • Philip J Barter
  • Richard Ceska
  • Alberto Corsini
  • Jean-Pierre Després
  • Patrick Duriez
  • Robert H Eckel
  • Marat V Ezhov
  • Michel Farnier
  • Henry N Ginsberg
  • Michel P Hermans
  • Shun Ishibashi
  • Fredrik Karpe
  • Tatsuhiko Kodama
  • Wolfgang Koenig
  • Michel Krempf
  • Soo Lim
  • Alberto J Lorenzatti
  • Ruth McPherson
  • Jesus Millan Nuñez-Cortes
  • Børge G Nordestgaard
  • Hisao Ogawa
  • Chris J Packard
  • Jorge Plutzky
  • Carlos I Ponte-Negretti
  • Aruna Pradhan
  • Kausik K Ray
  • Željko Reiner
  • Paul M Ridker
  • Massimiliano Ruscica
  • Shaukat Sadikot
  • Hitoshi Shimano
  • Piyamitr Sritara
  • Jane K Stock
  • Ta-Chen Su
  • Andrey V Susekov
  • André Tartar
  • Marja-Riitta Taskinen
  • Alexander Tenenbaum
  • Lale S Tokgözoğlu
  • Brian Tomlinson
  • Anne Tybjærg-Hansen
  • Paul Valensi
  • Michal Vrablík
  • Walter Wahli
Vis graf over relationer

In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Elevated plasma triglycerides, with or without low levels of high-density lipoprotein cholesterol (HDL-C), offer a key modifiable component of this common dyslipidemia, especially in insulin resistant conditions such as type 2 diabetes mellitus. The development of selective peroxisome proliferator-activated receptor alpha modulators (SPPARMα) offers an approach to address this treatment gap. This Joint Consensus Panel appraised evidence for the first SPPARMα agonist and concluded that this agent represents a novel therapeutic class, distinct from fibrates, based on pharmacological activity, and, importantly, a safe hepatic and renal profile. The ongoing PROMINENT cardiovascular outcomes trial is testing in 10,000 patients with type 2 diabetes mellitus, elevated triglycerides, and low levels of HDL-C whether treatment with this SPPARMα agonist safely reduces residual cardiovascular risk.

TidsskriftCardiovascular Diabetology
Udgave nummer1
StatusUdgivet - 4 jun. 2019

ID: 58297148