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The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

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Harvard

Tong, D, Constantinidou, A, Engelmann, B, Chamberlain, F, Thway, K, Fisher, C, Hayes, A, Fotiadis, N, Messiou, C, Miah, AB, Zaidi, SH, Benson, C, VAN DER Graaf, W & Jones, RL 2019, 'The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma' Anticancer Research, bind 39, nr. 9, s. 4891-4896. https://doi.org/10.21873/anticanres.13675

APA

Tong, D., Constantinidou, A., Engelmann, B., Chamberlain, F., Thway, K., Fisher, C., ... Jones, R. L. (2019). The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma. Anticancer Research, 39(9), 4891-4896. https://doi.org/10.21873/anticanres.13675

CBE

Tong D, Constantinidou A, Engelmann B, Chamberlain F, Thway K, Fisher C, Hayes A, Fotiadis N, Messiou C, Miah AB, Zaidi SH, Benson C, VAN DER Graaf W, Jones RL. 2019. The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma. Anticancer Research. 39(9):4891-4896. https://doi.org/10.21873/anticanres.13675

MLA

Vancouver

Tong D, Constantinidou A, Engelmann B, Chamberlain F, Thway K, Fisher C o.a. The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma. Anticancer Research. 2019 sep;39(9):4891-4896. https://doi.org/10.21873/anticanres.13675

Author

Tong, Daniel ; Constantinidou, Anastasia ; Engelmann, Bodil ; Chamberlain, Florence ; Thway, Khin ; Fisher, Cyril ; Hayes, Andrew ; Fotiadis, Nicos ; Messiou, Christina ; Miah, Aisha B ; Zaidi, Shane H ; Benson, Charlotte ; VAN DER Graaf, Winette ; Jones, Robin L. / The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma. I: Anticancer Research. 2019 ; Bind 39, Nr. 9. s. 4891-4896.

Bibtex

@article{c0fcbe5d5e294d17a5b56126ed806e9d,
title = "The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma",
abstract = "BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease.PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted.RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0{\%}) received local therapy, and 11 patients (20.8{\%}) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5{\%}). Patients who developed pleural effusion (n=5, 9.4{\%}) had poor outcome irrespective of treatment.CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.",
keywords = "Adolescent, Adult, Aged, Combined Modality Therapy, Disease Management, Female, Hemangioendothelioma, Epithelioid/mortality, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Pleural Effusion/pathology, Prognosis, Watchful Waiting, Young Adult",
author = "Daniel Tong and Anastasia Constantinidou and Bodil Engelmann and Florence Chamberlain and Khin Thway and Cyril Fisher and Andrew Hayes and Nicos Fotiadis and Christina Messiou and Miah, {Aisha B} and Zaidi, {Shane H} and Charlotte Benson and {VAN DER Graaf}, Winette and Jones, {Robin L}",
note = "Copyright{\circledC} 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.",
year = "2019",
month = "9",
doi = "10.21873/anticanres.13675",
language = "English",
volume = "39",
pages = "4891--4896",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "9",

}

RIS

TY - JOUR

T1 - The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

AU - Tong, Daniel

AU - Constantinidou, Anastasia

AU - Engelmann, Bodil

AU - Chamberlain, Florence

AU - Thway, Khin

AU - Fisher, Cyril

AU - Hayes, Andrew

AU - Fotiadis, Nicos

AU - Messiou, Christina

AU - Miah, Aisha B

AU - Zaidi, Shane H

AU - Benson, Charlotte

AU - VAN DER Graaf, Winette

AU - Jones, Robin L

N1 - Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

PY - 2019/9

Y1 - 2019/9

N2 - BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease.PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted.RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment.CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.

AB - BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease.PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted.RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment.CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.

KW - Adolescent

KW - Adult

KW - Aged

KW - Combined Modality Therapy

KW - Disease Management

KW - Female

KW - Hemangioendothelioma, Epithelioid/mortality

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

KW - Pleural Effusion/pathology

KW - Prognosis

KW - Watchful Waiting

KW - Young Adult

U2 - 10.21873/anticanres.13675

DO - 10.21873/anticanres.13675

M3 - Journal article

VL - 39

SP - 4891

EP - 4896

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 9

ER -

ID: 59280117