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Region Hovedstaden - en del af Københavns Universitetshospital

The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


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  • Daniel Tong
  • Anastasia Constantinidou
  • Bodil Engelmann
  • Florence Chamberlain
  • Khin Thway
  • Cyril Fisher
  • Andrew Hayes
  • Nicos Fotiadis
  • Christina Messiou
  • Aisha B Miah
  • Shane H Zaidi
  • Charlotte Benson
  • Winette VAN DER Graaf
  • Robin L Jones
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BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease.

PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted.

RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment.

CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.

TidsskriftAnticancer Research
Udgave nummer9
Sider (fra-til)4891-4896
Antal sider6
StatusUdgivet - sep. 2019
Eksternt udgivetJa

Bibliografisk note

Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

ID: 59280117